肿瘤能量代谢重排与转移关系

1、肿瘤能量代谢重排（reprograming）与转移2。肿瘤细胞即使在供氧充足的情况下，葡萄糖依旧向乳酸转换，这种代(aerobicglycolysis“Warburg(Warburgeffect)协调，产生代谢共生 (metabolism of symbiosis)。肿瘤组织存在着异常复杂的微环境重编程 (metabolic reprogramming)。肿瘤的能量代谢重编程是指肿瘤细胞中 ATP 的主要生成方式由葡萄糖的有氧氧化偶联18F-脱氧葡萄糖-PET/CT3。能量代谢是有机体在物质代谢过程中能量的产先锋理论-Warburg 效应 4。虽然糖酵解产能效率低，但对于快速增殖的肿瘤细胞而言

2、这却ATP，还能为新细胞的构筑提供多种生物大分子，从1.ATP6。reprogramming8。Venkatanarayanp63p73N37IAPPp539。他们I/IIp53快速退化，这为日后靶向 p53 缺失的肿瘤的治疗提供了参考。Jiang L 等人发现, TGF1EMT Snail1（FASNTGF1EMT10（PGC-1）入性乳腺癌的临床分析发现，PGC-1PGC-111。此外，被认为来源于间充质干细12-14。1B1617。在以双室模型代谢方式为主的肿瘤组织中，基质细胞发生过4其他氨基酸等支持肿瘤细胞的生长。而癌细胞摄取代谢产物的转运体单羧酸转运蛋白 1 表转运蛋白 4 进行自噬

3、和糖酵解为主的分解代谢，另一部分肿瘤细胞主要表达单羧酸转运蛋1ATPmicroRNA WaburgWarbugWarburg过调整能量代谢以适应其生物合成的需要 20（oxidativephosphorylation，OXPHOS）作为生物能量来源时，肿瘤细胞却更多地依赖于糖酵解， 这种转变称为“ Warburg 效应”。能量代谢重组（reprogrammingofenergy 些基因的调控， 也依赖于特定的物质（ 如谷氨酰胺等 。此 外， 缺氧诱导因子（hypoxia-induciblefactor，HIF）21。肿瘤细胞还可通过其他途径，如逆向“ Warburg 效应”和截断的三羧酸循环（

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