Melanin-probe-1-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemEMelaninprobe-1Cat.No.:HY-136404CASNo.:1420844-62-7分⼦式:C₁₂H₁₈FN₃O分⼦量:239.29作⽤靶点:Others作⽤通路:Others储存⽅式:Pureform-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:250mg/mL(1044.76mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM4.1790mL20.8951mL41.7903mL5mM0.8358mL4.1790mL8.3581mL10mM0.4179mL2.0895mL4.1790mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案，配制前请先配制澄的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的⼯作液，建议您现⽤现配，当天使⽤；澄的储备液可以根据储存条件，适当保存；以下溶剂前的百分⽐指该溶剂在您配制终溶液中的体积占⽐)：1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥6.25mg/mL(26.12mM);Clearsolution2.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥6.25mg/mL(26.12mM);ClearsolutionBIOLOGICALACTIVITY1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemE⽣物活性Melaninprobe-1⼀种于18F-吡啶酰胺的PET探针。Melaninprobe-1可⽤于恶性⿊⾊素瘤的PET显像。Melaninprobe-1具有较⾼的肿瘤靶向性、良好的肿瘤像学对⽐，理想的⽣物分布模式和体内稳定性好。体内研究Melaninprobe-1(3.7MBq;tailvein)exhibitshightumortargetingefficiency[1].Melaninprobe-1showshighinvivostabilityandfavorablepharmacokineticpropertiessuchasfastclearancefromurinalsystemandalmostbackgroundlevelofuptakesforallofthemajororgansat2h.ThehighselectivityandspecificityofMelaninprobe-1,asevidencedbythehightumor-to-nontumorratios,highlightthatMelaninprobe-1PEThashighpotentialtoimprovethemelanomadetection[1].AnimalModel:C57BL/6micebearingB16F10murinemelanomas[1]Dosage:3.7MBq(100μCi)Administration:TailveinResult:ThetumoruptakesofMelaninprobe-1were12.74±1.70,16.61±2.60,and16.87±1.23%ID/gat0.5,1,and2h,respectively.REFERENCES[1].LiuH,etal.Developmentof18F-labeledpicolinamideprobesforPETimagingofmalignantmelanoma.JMedChem.2013;56(3):895‐901.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuse/