Xanthinol-Nicotinate-Xanthinol-Niacinate-DataSheet-生命科学试剂-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemEXanthinolNicotinateCat.No.:HY-B1815CASNo.:437-74-1Synonyms:XanthinolNiacinate分⼦式:C₁₉H₂₆N₆O₆分⼦量:434.45作⽤靶点:Others作⽤通路:Others储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验H2O:250mg/mL(575.44mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.3018mL11.5088mL23.0176mL5mM0.4604mL2.3018mL4.6035mL10mM0.2302mL1.1509mL2.3018mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。BIOLOGICALACTIVITY⽣物活性XanthinolNicotinate(XanthinolNiacinate)⼀种⾎管扩张剂，可以直接作⽤于⼩动脉和⽑细⾎管的平滑肌。XanthinolNicotinate可以扩⼤⾎管，改⾎液流变学并降低外周⾎管阻⼒。体外研究XanthinolNicotinate(XanthinolNiacinate;2.76-276µM;for24hours)inhibitsHUASMCproliferationinadose-dependentmanner[2].XanthinolNicotinate(2.76-276µM;for24hours)dose-dependentlydecreasesthePDGFRmRNAand1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEPDGFR-βlevelsonthecellmembranesofHUASMCs[2].CellProliferationAssay[2]CellLine:humanumbilicalarterysmoothmusclecell(HUASMC)Concentration:2.76,27.6or276µMIncubationTime:for24hoursResult:InhibitedHUASMCproliferationinadose-dependentmanner.WesternBlotAnalysis[2]CellLine:HUASMCConcentration:2.76,27.6or276µMIncubationTime:for24hoursResult:Dose-dependentlydecreasedthePDGFRmRNAandPDGFR-βlevelsonthecellmembranesofHUASMCs.体内研究XanthinolNicotinate(XanthinolNiacinate;75mg/kg;IP)rapidlyandtransientlymodifiestumorpO2andthemaximalpO2valuesareobtained10to30minutesafterXanthinolNicotinateadministration[1].XanthinolNicotinateisabletoradiosensitizethetumorswhenapplying10GyofX-Raysduringthereoxygenationofthetumors(enhancementinradiationresponseof1.4)[1].AnimalModel:5week-oldmaleNMRImice[1]Dosage:75mg/kgAdministration:IPResult:RapidlyandtransientlymodifiedtumorpO2andMaximalpO2valueswereobtained10to30minutesafterXNadministration.REFERENCES[1].SegersJ,etal.UseofXanthinolNicotinateasaco-treatmentforradio-andchemo-therapyinexperimentaltumors.IntJCancer.2010Jan15;126(2):583-8.[2].BaiX,etal.Inhibitedproliferationofhumanumbilicalarterysmoothmusclecellsbyxanthinolnicotinate.MedBiolEngComput.2016Jun;54(6):891-8.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forres