EGTA-DataSheet-生命科学试剂-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrarieswww.MedChemEEGTACat.No.:HY-D0861CASNo.:67-42-5分⼦式:C₁₄H₂₄N₂O₁₀分⼦量:380.35作⽤靶点:Others作⽤通路:Others储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验H2O:10mg/mL(26.29mM;Needultrasonic)DMSO:1mg/mL(2.63mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.6292mL13.1458mL26.2916mL5mM0.5258mL2.6292mL5.2583mL10mM0.2629mL1.3146mL2.6292mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。BIOLOGICALACTIVITY⽣物活性EGTA⼀种特殊的钙离⼦螯合剂。EGTA在⽣理pH值(7.4)下，Kd为60.5nM，对Ca2+⽐对Mg2+有很⾼的特异性。EGTA显著抑制炎性巨噬细胞的底物粘附能⼒。体外研究EGTA,proposedasendodonticirrigant,decreasessubstrateadherencecapacityofinflammatorymacrophagesinatime-anddose-dependentmanner.TheEGTAconcentrationthatcausesanIC50is202mM.Chelatorsreactwithcalciumionsinthehydroxyapatitecrystalstoproduceametallicchelate.Removal1/2MasterofSmallMolecules—您⾝边的抑制剂⼤师www.MedChemEofcalciumionsfromthedentinemakesthedentinaltissuesofter,especiallythehydroxyapatite-richperitubulardentinandincreasesthediameterofexposeddentinaltubules[2].REFERENCES[1].HarrisRA,HanrahanJW.EffectsofEGTAoncalciumsignalinginairwayepithelialcells.AmJPhysiol.1994;267(5Pt1):C1426-C1434.doi:10.1152/ajpcell.1994.267.5.C1426[2].Segura-EgeaJJ,Jiménez-RubioA,Rios-SantosJV,Velasco-OrtegaE,Calvo-GutierrezJR.InvitroinhibitoryeffectofEGTAonmacrophageadhesion:endodonticimplications.JEndod.2003;29(3):211-213.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-