内容化学生物学

Chemical

Biology1.

Introduction

to

chemical

biologyPeng

Chen

Ph.DDepartment

of

Chemical

BiologyPKUWhat

is

Science?Science:The

effort

to

discover

and

increase

human

understanding

of

how

physical

reality

worksNovel

observationno

one

knows

before;

surprisingRational

explanationbased

on

logics;

use

mathematicsFrontiers

in

Science?Universe!Life!What

is

Technology?Technology

is

the

extension

of

our

humancapability,

in

order

to

satisfy

our

needs

or

wantsChinaRenaissanceFoodEnergyEnvironmentHealthWhat

is

Chemistry?Chemistry

is

Science

ofMoleculesStructures

and

properties

of

molecules?Interactions

between

molecules？Chemistry

is

also

Technology

of

MolecularEngineeringDesign

and

synthesisof

new

molecules?Utility

and

application

of

new

molecules?What

is

Biology?Biology

is

Science

of

LifeOrigin

and

classification

of

life?Mechanism

of

life

processes?Biology

also

studiesBiotechnologyAny

technological

application

that

uses

biologicalsystems,

living

organisms,

or

derivatives

thereof,

tomake

or

modify

products

or

processes

for

specific

useWhat

is

Biology?Biology

is

Science

of

LifeOrigin

and

classification

of

life?Mechanism

of

life

processes?Biology

also

studiesBiotechnologyAny

technological

application

that

uses

biologicalsystems,

living

organisms,

or

derivatives

thereof,

tomake

or

modify

products

or

processes

for

specific

useWhat

is

Biology?Biology

is

Science

of

LifeOrigin

and

classification

of

life?Mechanism

of

life

processes?Biology

also

studiesBiotechnologyAny

technological

application

that

uses

biologicalsystems,

living

organisms,

or

derivatives

thereof,

tomake

or

modify

products

or

processes

for

specific

useChemical

BiologyChemical

biology

is

a

scientific

disciplinespanning

the

fields

of

chemistry

and

biology

thatinvolves

the

application

of

chemical

techniquesand

tools,

often

compounds

producedthroughsynthetic

chemistry,

to

the

study

and

manipulationof

biological

systems.Chemical

Biology: Creation

and

inventionBiochemistry:

Description

and

cognitionJoseph

Priestley学科定义：化学生物学是一门利用外源的化学物质、化学方法或途径，在分子层面上对生命体系进行精准的修饰、调控和阐释的学科。1. “外源化学

(Exogenous

Chemistry)”的使用是化学生物化学生物学的定义和特征学的

思想，也是化学生物学区别于其他传统学科，尤其是生物化学等学科的根本性特征。“化学探针

(Chemical

Probe)”的开发与应用是化学生物学的

工具，也是化学生物学区别于其他传统学科，尤其是药物化学等学科的根本性特征。“分子精度

(Molecular

Precision)”的不断提高是化学生物学的

任务。“揭示生命本质并服务于化学”是化学生物学的

目标2.3.4.Interplay

between

chemistry

and

biologyChemistryBiologyMolecularprobesSyntheticmedicinesBiomimeticchemistryEngineeredbiosynthesisI.

Bio-oriented

synthetic

chemistryCentral

Scientific

QuestionHow

to

efficiently

synthesize

complex,fragile,

yet

bioactive

small

molecules

andmacromolecules?Diversity-orientedsynthesis

&CombinatorialchemistryBiomolecularmodification

&labeling

chemistryBiomolecularsynthesis:peptides,oligonucleotides,oligosaccharidesNatural

productssynthesis

&Asymmetriccatalysis2.

Extend

chemistry

research

by

usingbiological

methodsCentral

Scientific

Question:How

to

learn

from

biology

to

do

chemistrymore

efficiently

and

more

powerfully.Enzymatic

synthesisBiosynthetic

engineeringDirected

evolution

of

macromolecular

catalysts

andreceptors3.

Chemical

mechanisms

of

biologyCentral

ScientificQuestion:How

to

understand

or

interpret

life

as

themovements

of

an

assembly

of

molecules？Enzyme

inhibition

and

reactionmechanismsProtein

interaction

networks

&

Proteinpost-translational

modificationChemical

imaging

of

biological

processes4.

Extend

biology

researchby

usingchemistry

methodsCentral

ScientificQuestion:How

to

change

life

or

create

new

life

byusing

chemistry？Chemical

genetics

and

high-throughput

screeningUnnatural

biomolecularbiological

systemsogs

inMiniprotein-peptideSynthetic

biology近10年的

化学奖

（蓝色为和生物有关）1999

A.H.Zewail,飞秒光谱化学2000

A.J.Heeger,A.G.MacDiarmid,白川英树,导电高分子2001

W.S.Knowles,

治,K.

B.Sharpless,

手性催化

2002

J.B.

Fenn,田中耕一,K.Wuthrich,质谱与核磁技术

2003

P.Agre,R.Mackinnon,

通道蛋白2004

A.Ciechanover,A.Hershko,I.Rose,

泛素调控蛋白降解方法2005

Y.Chauvin,R.H.

Grubbs,

R.R.Schrock,有机2006

R.D.Kornberg,真核转录的分子机制2007

G.Ertl,固体表面的化学过程2008

O.

Shimomura,M.Chalfie,

R.Y.Tsien,荧光蛋白2009

ThomasSteitz，Venkatraman

Ramakrishnan，Ada

E.

Yonath，核糖体的结构与功能2010

Richard

F.

Heck，Ei-ichi

Negishi，Akira

Suzuki钯催化的偶联反应在有机

中的应用2011

Dan

Shechtman

准晶体2012

Robert

Lefkowitz，Brian

Kobilka

，G蛋白偶联受体Peter

Schultz揭示生命运动的化学本质发展生命调控的化学方法提供生命研究的化学技术化学生物学—一个新兴的交叉学科Stuart

Schreiber化学学院化学生物学系运用化学的原理、语言和工具认识生命问题20011996

哈佛大学化学与化学生物学系BiologyChemistryTheInterface

of

Chemistry

and

BiologyAs

a

Chemist:

Where

and

How?Topics

that

are

going

to

be

covered…Part

I.

Introduction(引言)Lecture

1.

When

Chemistry

meets

BiologyPart

II.

Molecular

Chemical

Biology（分子化学生物学）Lecture

2.

Nucleic

acids

and

themodificationsLecture3.

Amino

acids,

Peptides

and

ProteinsLecture

4.

Natural

and

Engineered

ProteinsLecture

5.

Unnatural

Amino

AcidsLecture

6.

Metals

in

biologyLecture

7.

Interactionsof

Biomolecules（Note:Chemical

Biology

on

Glycan,lipids,and

other

small

molecules/metabolites

will

becovered

by

《化学生物学基础（I）》）Part

III.

Chemical

Biology

Techniques(化学生物学技术)Lecture

8.

X-omicsLecture

9. Molecular

Biology

TechniquesLecture

10.

Modern

Biology

TechniquesPart

IV.

Chemical

Biology

Frontiers(化学生物学前沿专题)Lecture

11.

Frontier

PresentationLecture

12.

Frontier

PresentationLecture13.

Frontier

PresentationLecture

14.

Selected

topics

on

Chemical