NHC-diphosphate-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•Agonists•ScreeningLibrariesNHC-diphosphateCat.No.:HY-135867DCASNo.:39023-73-9分⼦式:C₉H₁₅N₃O₁₂P₂分⼦量:419.18作⽤靶点:EndogenousMetabolite;Enterovirus;HCV;Topoisomerase;SARS-CoV作⽤通路:MetabolicEnzyme/Protease;Anti-infection;CellCycle/DNADamage储存⽅式:-20°C,protectfromlight,storedunderargon*Insolvent:-80°C,6months;-20°C,1month(protectfromlight,storedunderargon)溶解性数据体外实验H2O:160mg/mL(381.70mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.3856mL11.9281mL23.8561mL5mM0.4771mL2.3856mL4.7712mL10mM0.2386mL1.1928mL2.3856mL请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存⽅式和期限。BIOLOGICALACTIVITY⽣物活性NHC-diphosphateNHC(HY-125033)的活性胞内磷酸化代谢物(intracellularmetabolite)，以⼆磷酸盐的形式存在。NHC⼀种嘧啶核糖核苷，⼀种有效的抗病毒剂(anti-virusagent)。NHC有效抑制委内瑞拉马脑炎病毒(VEEV)、孔肯亚病毒(CHIKV)和丙型肝炎病毒(HCV)的复制。体外研究Huh-7cellsareincubatedwith(10-50μM;4h)NHCoraMcGuiganphosphoramidateprodrugofNHC.IntracellularlevelsoftheparentalcompoundsandphosphorylatedmetabolitesaremeasuredusingLC-MS/MS.SmallamountsofNHC-monophosphate(MP)andNHC-diphosphate(DP;HY-135867D)canbeobserved,whileNHC-triphosphateremainsthemostabundantmetabolite.[1].REFERENCES1/2[1].BrendaIHernandez-Santiago,etal.Metabolismoftheanti-hepatitisCvirusnucleosidebeta-D-N4-hydroxycytidineindifferentlivercells.AntimicrobAgentsChemother.2004Dec;48(12):4636-42[2].MaryamEhteshami,etal.Characterizationofβ-d-N4-HydroxycytidineasaNovelInhibitorofChikungunyaVirus.McePdfHeightMedChemExpress(MCE)只为有资质的科研机构、医药企业基于科学研究或药证申报的⽤途提供医药研发服务，

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