BAI1-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEBAI1Cat.No.:HY-103269CASNo.:335165-68-9分⼦式:C₁₉H₂₁Br₂N₃O分⼦量:467.2作⽤靶点:Bcl-2Family;Apoptosis作⽤通路:Apoptosis储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:18.67mg/mL(39.96mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.1404mL10.7021mL21.4041mL5mM0.4281mL2.1404mL4.2808mL10mM0.2140mL1.0702mL2.1404mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥1.87mg/mL(4.00mM);Clearsolution1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE2.请依序添加每种溶剂：10%DMSO>>90%cornoilSolubility:≥1.87mg/mL(4.00mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性BAI1⼀种选择性的凋亡因⼦BAX变构抑制剂。BAI1结合BAX并变构抑制其激活。BAI1具有潜⼒⽤于BAX依赖性细胞死亡介导的疾病的研究[1]。IC50&TargetBax体外研究BAI1selectivelyinhibitsBAX-mediatedapoptoticcelldeath[1].BAI1showsinhibitionoftBID(HY-100464)-inducedBAX-mediatedmembranepermeabilizationinadosedependentmannerwithanIC50of3.3μΜ[1].ApoptosisAnalysis[1]CellLine:MouseMEFConcentration:0.3125μM,0.625μM,1μM,1.25μM,1.5μM,2.5μM,3μM,4μM,54μM,104μMIncubationTime:8hoursResult:InhibitedcelldeathinBAX-dependentmanner.户使⽤本产品发表的科研⽂献•UniversityofRijeka.FacultyofMedicine.2021Jun.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].GarnerTP,etal.Small-moleculeallostericinhibitorsofBAX.NatChemBiol.2019Apr;15(4):322-330.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-