RS-MCPG-alpha-MCPG-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(RS)-MCPGCat.No.:HY-100371CASNo.:146669-29-6Synonyms:alpha-MCPG分⼦式:C₁₀H₁₁NO₄分⼦量:209.2作⽤靶点:mGluR作⽤通路:GPCR/GProtein;NeuronalSignaling储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验1MNaOH:100mg/mL(478.01mM;ultrasonicandadjustpHto10withNaOH)DMSO:6mg/mL(28.68mM;Needultrasonicandwarming)H2O:<0.1mg/mL(ultrasonic;heatto80°C)(insoluble)MassSolvent1mg5mg10mgConcentration制备储备液1mM4.7801mL23.9006mL47.8011mL5mM0.9560mL4.7801mL9.5602mL10mM0.4780mL2.3901mL4.7801mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性(RS)-MCPG(alpha-MCPG)⼀种竞争性和选择性I/II组代谢型⾕氨酸受体(mGluR)拮抗剂。(RS)-MCPG阻断1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemETBS诱导的幼年和新⽣⼤⿏海马神经元的转变。IC50&TargetgroupI/groupIImGluR[1]体外研究MCPGcanblockgroupI(mGluR1andmGluR5)andgroupIIreceptors(mGluR2andmGluR3)[2].体内研究(RS)-MCPG(alpha-MCPG;500μM)blockstheTBS-inducedshiftsinEGABAineitherjuvenileorneonatalneurons[1].Pretreatmentwiththelowdoseof(RS)-MCPG(25nM;i.c.;daily;5days)significantlyattenuatesamphetamine-inducedlocomotoractivityin10-day-oldmaleandfemaleratsofSprague-Dawleydescent[2].户使⽤本产品发表的科研⽂献•FrontCellNeurosci.2019Jun25;13:276.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].YangBetal.RegulationofGABAEquilibriumPotentialbymGluRsinRatHippocampalCA1Neurons.PLoSOne,2015Sep21,10(9):e0138215.[2].FionaYeuk-LunChoi,etal.Theeffectsof(RS)-MCPGonamphetamine-inducedsensitizationinneonatalrats.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379