C-176-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEC-176Cat.No.:HY-112906CASNo.:314054-00-7分⼦式:C₁₁H₇IN₂O₄分⼦量:358.09作⽤靶点:STING作⽤通路:Immunology/Inflammation储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:62.5mg/mL(174.54mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.7926mL13.9630mL27.9259mL5mM0.5585mL2.7926mL5.5852mL10mM0.2793mL1.3963mL2.7926mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性C-176⼲扰素因刺激受体(STING)的强效共价抑制剂。IC50&TargetSTING[1].体外研究C-176stronglyreducesSTING-mediated,butnotRIG-I-orTBK1-mediated,IFNβreporteractivity.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEPretreatmentwithC-176markedlyreducetheCMA-mediatedinductionofserumlevelsoftypeIIFNsandIL-6[1].体内研究C-176(750/375nmolC-176permousein200μLcornoil)significantlyreducestheCMA-mediatedinductionofserumlevelsoftypeIIFNsandIL-6.,withoutsignificanttoxicity[1].C-176resultsinasignificantreductioninserumlevelsoftypeIIFNsandinastrongsuppressionofinflammatoryparametersintheheart,withnoevidentsignsofoverttoxicityTrex1−/−mice[1].C-176demonstratesmarkedameliorationofvarioussignsofsystemicinflammationinTrex1−/−mice[1].AnimalModel:WTtypemice.Dosage:750/375nmolC-176permousein200μLcornoil(~1.34/0.67mg/mL).Administration:Intraperitoneally,once.Result:SignificantlyreducedSerumlevelsoftypeIIFNsandIL-6.户使⽤本产品发表的科研⽂献•JClinInvest.2021Oct15;131(20):e136329.•Neuron.2022Nov4;S0896-6273(22)00961-8.•AdvSci(Weinh).2021Jan6;8(5):2002738.•CancerRes.2021Apr5;canres.3738.2020.•CancerRes.2021Feb15;canres.2370.2020.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].HaagSM,etal.TargetingSTINGwithcovalentsmall-moleculeinhibitors.Nature.2018Jul;559(7713):269-273.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Te