宣白承气汤联合西医常规治疗慢性阻塞性肺疾病急性加重期系统评价

性加重期系统评价Abstract：ObjectiveToreviewtheefficacyandsafetyofXuanbaiChengqi Decoction combined with western medicine for thetreatmentofexacerbationofchronicobstructivepulmonarydisease（AECOPD）systematically.MethodsRandomizedcontrolledtrialsofmodified Xuanbai Chengqi Decoction combined with WesternmedicineroutinetreatmentandWesternmedicineinthetreatmentofAECOPDwereretrievedfromCNKI，VIP，WanfangDataandPubmeddatabases.TheCochraneHandbookforSystematicReviewswasusedforliteraturequalityevaluationanddataextraction，andRevMan5.3wasusedformeta-analysisonclinicalefficacyindicators.ResultsTotallytwelvearticleswereincluded.Thetotaleffectiverateofthetreatmentgroupwashigherthanthatinthecontrolwithle，%I（，，0Comparedwiththecontrolthetreatmentgroupsignificantlyreducedthepercentageofneutrophils，inflammatorymarkerssuchasC-reactiveproteinandarterialbloodcarbondioxidepartialpressure，andsignificantlyincreasedthepercentageofforcedyenetd1，dl（FVC）asapercentageofpredictedvalue，FEV1/FVC，arterialbloodpHandarterialoxygenpartialwithstatisticalsignificance.Noseriousadversereactionswerereportedintheliterature.ConclusionModifiedXuanbaiChengqiDecoctioncombinedwithwesternmedicineinthetreatmentofAECOPDhassignificantefficacy.However，duetothesmallamountofliteratureandsmallsamplethequalityofthestudyisanditsclinicalefficacydyleyrandomizedtrialstofurtherverify.

large-sample，andKeywords：XuanbaiChengqiDecoction;acuteexacerbationofchronicobstructivepulmonarydisease;randomizedcontrolledtrials;Meta-analysis慢性阻塞性肺疾病（chronicobstructivepulmonarydisease，COPD）是全球无法治愈的主要健康负担。慢性阻塞性肺疾病急性加AECOPD的常规治疗以止咳抗感染、化痰止痉、低浓度氧疗等为主。宣白承气AECOPD患者多以咳嗽、气短或喘息加重、痰量增多呈脓性或黏液脓性、发热为主，同时伴有便秘，与AECOPD的随机对照试验Meta分析，AECOPD提供循证医学证据。资料与方法数据来源中文文献检索数据库包括中国生物医学文献数据库（、中（（万方数据（慢阻肺R慢性阻塞性肺病ORCOPDOROR慢性阻塞性肺OROR宣白承气OROROR试验PubmedobstructivepulmonarydiseaseORExacerba