2013实验血液学课件合集

Figure22-Copyright©2005ElsevierInc.(USA)All VerylargeinAbundantpalestaining smwithgranules. etsareformedbyfragmentationof Abarenucleus1994年发现在脊椎动物（如鱼和鸟），所有的循μm），体积4700±100fl（红细胞为85-100fl）；最大者直径50-60μm，体积65000-100000fl巨核细胞为多倍体(4N-64N，平均新生儿与成人巨核细胞调控的区Thehighproliferativerateandthesmallsizeofneonatalmegakaryocytesare smicmaturation,whichallowsfetusesandneonatestoproducelargenumbersofsmallbuthighlycyto smicallymaturemegakaryocytes.Therearesubstantialmoleculardifferencesbetweenfetal/neonatalandadultmegakaryocytes,leadingtotheincreasingunderstandingthatfetal/neonatalmegakaryopoiesisisregulatedbyadevelopmentalstagespecificinter yofpathwaysthatsimultaneouslystimulateproliferationandcyto LiuZ,etal.CurrOpinHematol2011,18:330-巨核细胞的分核内有丝（核内或多倍体化小鼠研究表明：巨核细胞进入有丝后可见：核膜重新组装后末期直接进入下一个DNA复 时：CyclinD3增加，CyclinB1水平下降，依赖于CyclinB1的巨核细胞分化的分子机巨核细早期巨核细胞祖细晚期巨核细胞祖细 成血小调控因 但对核 IFN-α和IFNβ：抑制meg-CFCIFN-γ：促进meg-CFC的生巨核细胞的转录调MalingeS,etal.Blood2013,121:2440-Regulationof血小板的生成与释确切机理不<8N的巨核细胞不能形成血小每毫升血每天生成35000-45000个血小当需求增加时，血小板产量可增加6Majorevents etformationandreleasefromFigure105-Copyright©2005ElsevierInc.(USA)All 巨核细胞形成血小板的机etterritory etPulmonaryetterritory支持点：电镜可观察到这些血小板领不支持点：动态过程不明，核巨核细胞 et也称为Flow肺脏血小板生成模血小板大小的调大体而言，血小板数增加则MPVTPO对大小的调节机理不不同种属，数量不同：小鼠正常1200×109/L，MPV为4.7fl；猪的正常30×109/L，MPV为Primaryimmunethrombocytopenia(primaryITP)isanautoimmunedisordercharacterizedbyisolatedthrombocytopenia(peripheralbloodetcount<100x109/l)intheabsenceofothercausesordisordersthatmaybeassociatedwiththrombocytopenia.ThediagnosisofprimaryITPremainsoneofexclusion.In1950DrWilliamHarringtoninfusedhimself smafromanITPpatientanddevelopedseverebuttransientthrombocytopeniaSincethen etdestructioninITPisbelievedtobemediatedby etautoantibodiesHarringtonetJLabClinMed1951,38:1- Y

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LiH,etal.SeminHematol2013;50(Suppl1):S116-26.QiA,etal.JClinImmunol.2013;33(3):577-85.GeJ,et ets.2013,24(6):448-MaL,etal.ThrombHaemost.2012,107(5):937-LiHY,etal.HumImmunol2012,73:240-MaL,etal.MolImmunol2011,48(12-13):1525-1531ChenZP,etal.HumImmunol2011,72(6):486-91WangT,etal.CritRevOncolHematol.2011,77:172-GuD,etal.HumImmunol2010,71:586-ZhaoH,et ets.2010;21(2):132-ZhaoH,etal.ActaHaematol2009;122(1):31-35DuW,etalHumImmunol.2009;70(6):398-402ZhouZ,etal.Autoimmunity.2009;42(2):112-9ChenZ,etal.JClinImmunol,2008,28:399-404ZhouZ,etal.CritRevOncol/Hematol2008,65(1):21-31Chen