Ensitrelvir-fumarate-S-217622-fumarate-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEEnsitrelvirfumarateCat.No.:HY-143216ACASNo.:2757470-18-9Synonyms:S-217622fumarate分⼦式:C₂₆H₂₁ClF₃N₉O₆分⼦量:647.95作⽤靶点:SARS-CoV;VirusProtease作⽤通路:Anti-infection储存⽅式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性数据体外实验DMSO:50mg/mL(77.17mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM1.5433mL7.7166mL15.4333mL5mM0.3087mL1.5433mL3.0867mL10mM0.1543mL0.7717mL1.5433mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Ensitrelvir(S-217622)fumarate第⼀个具有⼝服活性的，⾮共价的、⾮肽SARS-CoV-23CL蛋⽩酶抑制剂(IC50=13nM)。体外研究Inacytopathiceffect(cpe)-inhibitionassayofSARS-CoV-2infectedVeroE6/TMPRSS2cells,EnsitrelvirfumarateshowstheEC50valuesareapproximately0.4μMforbothwild-typevirusandAlpha,Beta,Gamma1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEandDeltavariants.EC50valuesforSARS-CoVandMERS-CoVwere0.21and1.4μMrespectively[1].体内研究Ensitrelvirfumaratedose-dependentlyinhibitsintrapulmonaryreplicationofSARS-CoV-2inmice[2].REFERENCES[1].McKimm-BreschkinJL,etal.COVID-19,InfluenzaandRSV:Surveillance-informedpreventionandtreatment-Meetingreportfromanisirv-WHOvirtualconference.AntiviralRes.2022;197:105227.[2].YutoUnoh,etal.DiscoveryofS-217622,aNon-CovalentOralSARS-CoV-23CLProteaseInhibitorClinicalCandidateforTreatingCOVID-19.bioRxiv2022.01.26.477782.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;0