Posovolone-Co-134444-DataSheet-生命科学试剂-MedChemExpress

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEPosovoloneCat.No.:HY-141795CASNo.:256955-84-7Synonyms:Co134444分⼦式:C₂₆H₄₀N₂O₃分⼦量:428.61作⽤靶点:Others作⽤通路:Others储存⽅式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性数据体外实验DMSO:100mg/mL(233.31mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.3331mL11.6656mL23.3312mL5mM0.4666mL2.3331mL4.6662mL10mM0.2333mL1.1666mL2.3331mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。体内实验请根据您的实验动物和给药⽅式选择适当的溶解⽅案。以下溶解⽅案都请先按照InVitro⽅式配制澄的储备液，再依次添加助溶剂：(为保证实验结果的可靠性，澄的储备液可以根据储存条件，适当保存；体内实验的⼯作液，建议您现⽤现配，当天使⽤；以下溶剂前显⽰的百分⽐指该溶剂在您配制终溶液中的体积占⽐；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的⽅式助溶)1.请依序添加每种溶剂：10%DMSO>>90%(20%SBE-β-CDinsaline)1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemESolubility:≥2.5mg/mL(5.83mM);ClearsolutionBIOLOGICALACTIVITY⽣物活性Posovolone(Co134444)⼀种具有⼝服活性的有助于睡眠的神经活性类醇。Posovolone具有抗惊厥和抗焦虑样活性以及共济失调作⽤。体外研究Inmice,Co134444(0.5-10mg/kg,IP,15min;1-60mg/kg,PO;30min)demonstratesefficacyagainstpentylenetetrazol(PTZ)-inducedseizureswithanED50of3.3mg/kgafterIPadministrationand9.8mg/kgorally.Similarly,protectionagainstmaximalelectroshock(MES)isobservedwithanED50of4.8mg/kgIPand20.6mg/kgPO.Inrats,Co134444(10-40mg/kg;PO;30min)protectsagainstPTZ-inducedseizuresandMES-inducedseizureswithanED50of23.6mg/kgand25.3mg/kg,respectively[1].REFERENCES[1].VanoverKE,etal.BehavioralcharacterizationofCo134444(3alpha-hydroxy-21-(1'-imidazolyl)-3beta-methoxymethyl-5alpha-pregnan-20-one),anovelsedative-hypnoticneuroactivesteroid.Psychopharmacology(Berl).2001;155(3):285-291.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-37