Niclofolan-BAY-9015-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemENiclofolanCat.No.:HY-113715CASNo.:10331-57-4Synonyms:BAY9015;Menichlopholan;Menichlofolan;Bilevon分⼦式:C₁₂H₆Cl₂N₂O₆分⼦量:345.09作⽤靶点:Parasite作⽤通路:Anti-infection储存⽅式:4°C,protectfromlight*Insolvent:-80°C,6months;-20°C,1month(protectfrom

light)溶解性数据体外实验DMSO:100mg/mL(289.78mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制备储备液1mM2.8978mL14.4890mL28.9779mL5mM0.5796mL2.8978mL5.7956mL10mM0.2898mL1.4489mL2.8978mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；⼀旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存⽅式和期限：-80°C,6months;-20°C,1month(protectfromlight)。-80°C储存时，请在6个⽉内使⽤，-20°C储存时，请在1个⽉内使⽤。BIOLOGICALACTIVITY⽣物活性Niclofolan(BAY9015)⼀种具有⼝服活性的驱⾍剂。Niclofolan可⽤于寄⽣⾍感染相关的研究。体外研究Niclofolan(0.12mg/mL,60min)iseffectiveagainstGyrodactylussp.underinvitroconditions[3].CellViabilityAssay[3]1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemECellLine:Gyrodactylussp.(parasite)Concentration:0.12mg/mLIncubationTime:60minResult:ReducedthenumberofliveGyrodactylussp.By100%.体内研究Niclofolan(2mg/kg,intramuscularinjection)iseffectiveagainstfasciolahepaticainfectedsheep[2].Niclofolan(1or2mg/kg,oralgavage)showstherapeuticeffectsagainstP.iloktsuenesisinfectedrats[4].AnimalModel:fasciolahepaticainfectedsheep[2]Dosage:2mg/kgAdministration:IntramuscularinjectionResult:Showedeffectivenessagainsttheinfectionandproducednountowardeffectsexceptfortransientsignsofpainatthesiteofinjection.AnimalModel:RatsinfectedwithP.iloktsuenesis[4]Dosage:1mg/kg,dailyfor3days;2mg/kgeveryotherdayfor2times.Administration:OralgavageResult:Reducedthewormsinrats.REFERENCES[1].TEckhardt,Treatmentofhumanfascioliasiswithniclofolan.Gastroenterology.1981Oct;81(4):795-8.[2].BHAli,THassan,etal.TheeffectofniclofolanondesertsheepexperimentallyinfectedwithimmatureFasciolagigantica.JVetPharmacolTher.1985Dec;8(4):398-403.[3].SantamarinaM.T.,etal.AnthelmintictreatmentagainstGyrodactylussp.infectingrainbowtroutOncorhynchusmykiss.DiseasesofAquaticOrganisms,199110(1):39-43.[4].RimHJ,etal.Expermentalchemotherapeuticeffectsofniclofolan(Bayer9015,Bilevon)ontheanimalsinfectedwithParagonimuswestermaniorP.iloktsuenensis.TheKoreanJournalofParasitology,1976,14(2):140-146.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forr