实验室常用化疗药物

1紫杉醇(paclitaxol)分子式：C47H51NO14分子量：853.92CAS号：33069-62-4药理：促进微管聚合和稳定已聚合的微管，抑制有丝分裂。关键词：tubulinbinding，mitosisinhibition代表文献： WallME.Camptothecinandtaxol:discoverytoclinic--thirteenthBruceF.CainMemorialAwardLecture.Cancerresearch.1995,55(4):753-60.全文链接：/pubmed/78507852多烯紫杉醇(Docetaxel)分子式：C43H53NOm分子量：807.88CAS号：114977-28-5

关键词：microtubulesbinding,stabilizedmicrotubles,关键词：microtubulesapoptosis代表文献：YvonAM,WadsworthP,JordanMA(April1999).”TaxolSuppressesDynamicsofIndividualMicrotubulesinLivingHumanTumorCell.”Mol.Biol.Cell10(4):947-59.3阿霉素(Doxorubicin/Adriamycin)分子式:C27H29NO11分子式:C27H29NO11分子量:579.99CAS号:23214-92-8关键词:代表文献:关键词:代表文献:DNAintercalating,macromolecularbiosynthesisinhibitionMomparlerRL,KaronM,SiegelSE,AvilaF(August1976)"EffectofadriamycinonDNA,RNA,andproteinsynthesisincell-freesystemsandintactcells.CancerRes36(8):2891-5.4毗柔比星(Pirarubicin)分子式：c32h37noi2分子量：627.63CAS号：72496-41-4关键词：intercalating,DNAandRNAsynthesisinhibition,topoisomeraseIIenzymeinhibition文献：ZhengSE,Pirarubicininhibitsmultidrug-resistantosteosarcomacellproliferationthroughinductionofG(2)/Mphasecellcyclearrest.ActaPharmacolSin.2012,5网址：/pubmed/225807405 5-氟尿嘧啶(5-Flurouracil)分子式：C4H3FN2O2分子量：130.08CAS号：51-21-8X"关键词：suicideinhibitor,thymidylatesynthaseinhibition文献：LongleyDB,HarkinDP,JohnstonPG(May2003).”5-fluorouracil:mechanismsofactionandclinicalstrategies”.Nat.Rev.Cancer3(5):

330-8.doi:10.1038/nrc10746盐酸伊立替康(IrinotecanHydrochloride)分子式：C33H38N4O6-HCI-3H2°分子量：677.19CAS号：100286-90-6关键词：topoisomeraseIenzymeinhibition文献:O'DwyerPJ,CatalanoRB(October2006).”Uridinediphosphateglucuronosyltransferase(UGT)1A1andirinotecan:practicalpharmacogenomicsarrivesincancertherapy"J.Clin.Onc(24(28):4534-8.doi:10.1200/JCO.2006.07.30317索拉菲尼(sorafenib)分子式：CHClFNO116 343分子量：464.825CAQ号・ zHHCAS号：284461-73-0HH°T...文献:关键词：tyrosineproteinkinasesinhibition,Rafkinasesinhibition文献:KeatingGM,SantoroA.(2009).”Sorafenib:AReviewofitsUsein

AdvancedHepatocellularCarcinoma"Drugs69(2):223240.doi:10.2165/00003495-200969020-000068替尼泊苷(Teniposide)分子式：C32H32O13S分子量：656.655CAS号:CAS号:29767-20-2'关键词DNAandDNA-proteincross-linksbreak,关键词topoisomeraseIIenzymeinhibition文献:AnejaR,Multidrugresistance-associatedprotein-overexpressingteniposide-resistanthumanlymphomasundergoapoptosisbyatubulin-bindingagent.CancerRes.2008网址：/pubmed/183166149舒尼替尼(Sunitinib)分子式：C22H27FN4O2分子量：398.474CAS号：341031-54-7关键词:关键词:文献:multiplerecepto