版权说明：本文档由用户提供并上传，收益归属内容提供方，若内容存在侵权，请进行举报或认领
文档简介
AdrenergicagonistsoverviewTheadrenergicdrugsaffectreceptorthatarestimulatedbynorepinephrineorepinephrineTheadrenergicneuronAdrenergicneuronsreleasenorepinephrineastheneurotransmitter.CNS,andbetweengangliaandtheeffectororgansinsympatheticnervoussystem.NeurotransmissionatadrenergicneuronsSynthesisofnorepiephrineStorageofnorepiephrineinvesiclesReleaseofnorepiephrine
BindingbyreceptorRemovalofnorepiephrinePotentialfatesofrecapturednorepiephrineAdrenergicreceptor
,wereinitiallyidentifiedonthebasisoftheirresponsestheadrenergicagonists,epinephrine,norepinephrine,isoproterenol
1receptorshaveahigheraffinityforphenylephrine.Thedrugclonidineselectivelybindsto2receptors
1receptors
thesereceptorsarepresentonthepostsynapticmembraneoftheeffectororgans.G-proteincoupling
2receptorsLocatedprimarilyonthepresynapticnerveendingsandonothercells.Thestimulationofthe
2receptorscausesfeedbackinhibitionoftheongoingreleaseofnorepinephrinefromthestimulatedadrenergicneuronreceptorCharacterizedbyastrongresponsetoisoproterenol.
1receptorand2receptorResultsinactivationofadenylyl
cyclaseandthereforeincreasedconcentrationofcAMPwithinthecellDistributionofreceptorsVasculaturetoskeletalmusclehaveboth1and2receptors,butthe2receptorspredominate.Theheartcontainspredominantly1receptorsDesensitizationofreceptorsProlongedexposuretothecatecholaminesreducestheresponsivityofthesereceptors.CharacteristicsofadrenergicagonistsDerivativesof-phenylethylamineCatecholamines:sympathomimeticaminesthatcontainthe3,4-dihydroxybenzenegroupNon-catecholamines:lackingthecatecholhydroxylgroupshavelongerhalf-lives.MechanismofactionofadrenergicagonistsDirect-actingagonistsindirect-actingagonistsMixed-actionagonistsDirect-actingadrenergicagonistsEpinephrineissynthesizedfromtyrosineintheadrenalmedullaandreleased.Interactswithbothandreceptors.Atlowdoses,effects(vasodilation)onthevascularsystempredominate,whereasathighdoses,effects(vasoconstriction)arestrongest.actionsCardiovascular:strengthenthecontractilityofthemyocardium(1effect)Respiratory:causespowerfulbronchodilation(2effect)Hyperglycemia:lipolysisTherapeuticusesBronchospasm:emergencytreatmentofanyconditionoftherespiratorytractwherethepresenceofbronchoconstrictionhasresultedindiminishedrespiratoryexchange.AcuteasthmaAnaphylacticshockTherapeuticusesGlaucoma:epinephrinesolutionreduceintraocularpressureinopen-angleglaucoma.Anaphylacticshock:forthetreatmentofTypeIhypersensitivityreactioninresponsetoallergensInanesthetics:increasethedurationofthelocalanesthesiaPharmacokineticsIntravenouslyforthemostrapidonsetofactionSubcutaneously,byendotrachealtube,byinhalation,ortopicallytotheeyeOraladministrationisineffectiveAdverseeffectsCNSdisturbance:anxiety,fear,tension,headache,andtremorHemorrhage:inducecerebralhemorrhageCardiacarrhythmias:norepinephrineCardiovascularactionsVasoconstrictionBaroreceptorreflexEffectofatropinepretreatment:TherapeuticusesIsusestotreatshockbecauseitincreasesvascularresistanceOtheractionsofnorepinephrinearenotconsideredclinicallysignificant.Itisneverusedforasthma.IsoproterenolIsoproterenolisadirect-actingsyntheticcatecholamine.Stimulatesbothbeta1andbeta2adrenergicreceptors.actionsCardiovascular:increaseheartrateandforceofcontraction,causeincreasedcardiacoutput.Beta2onarteriolesofskeletalmuscleresultinadecreasedperipheralresistanceMayincreasesystolicbloodpressureslightlypulmonaryAprofoundandrapidbronchodilationisproducedbythedrugOthereffects:otheractionsonbetareceptor,suchasincreasesinbloodsugarandincreasedlipolysisTherapeuticusesStimulateheartinemergencysituationsRarelyusedasbronchodilatorinasthmadopamineDopamine,theimmediatemetabolicprecursorofnorepinephrine
CanactivatealphaandbetaadrenergicreceptorsActionsCardiovascular:stimulatoryeffectonthebeta1receptorsoftheheart,havingbothinotropicandchronotropiceffects.Athighdoses,vasoconstrictionRenalandvisceral:dopaminedilatesrenalarteriolesbyactivatingdopaminergicreceptors,thusincreasesbloodflowtothekidneysandotherviscera TherapeuticusesShock:dopamineisthedrugofchoiceforshock.Itraisesthebloodpressurebystimulatingtheheart(beta1action).Dopamineisfarsuperiortonorepinephrine.AdrenergicantagonistsOverview:bindtoadrenoceptorsbutdonottriggertheusualreceptor-mediatedintracellulareffectsAlphaadrenergicblockingagentsReducesthesympathetictoneofthebloodvessels,resultingindecreasedperipheralvascularresistance.PhenoxybenzamineNon-selective,alpha1postsynapticandalpha2presynapticreceptorsLastabout24hafterasingleadministrationActionsCardiovasculareffects:thedecreasedperipheralresistanceprovokesareflextachycardiaEpinephrinereversal:reversethealphaagonistactionsofepinephrineTherapeuticusesIsusedinthetreatmentofpheochromocytoma,acatecholamine-secretingtumorofcellsderivedfromtheadrenalmedul
温馨提示
- 1. 本站所有资源如无特殊说明，都需要本地电脑安装OFFICE2007和PDF阅读器。图纸软件为CAD,CAXA,PROE,UG,SolidWorks等.压缩文件请下载最新的WinRAR软件解压。
- 2. 本站的文档不包含任何第三方提供的附件图纸等，如果需要附件，请联系上传者。文件的所有权益归上传用户所有。
- 3. 本站RAR压缩包中若带图纸，网页内容里面会有图纸预览，若没有图纸预览就没有图纸。
- 4. 未经权益所有人同意不得将文件中的内容挪作商业或盈利用途。
- 5. 人人文库网仅提供信息存储空间，仅对用户上传内容的表现方式做保护处理，对用户上传分享的文档内容本身不做任何修改或编辑，并不能对任何下载内容负责。
- 6. 下载文件中如有侵权或不适当内容，请与我们联系，我们立即纠正。
- 7. 本站不保证下载资源的准确性、安全性和完整性, 同时也不承担用户因使用这些下载资源对自己和他人造成任何形式的伤害或损失。
最新文档
- 痛经护理健康知识库
- 2026生物医用材料行业技术突破与市场需求规模的投资评估文献报告
- 电气巡检规程知识测试题及答案
- 2026中国智能养殖传感器自动化管理与经济效益研究报告
- 2026中国石油化工行业产业链现状调研及产业升级规划
- 2026中国智能无人配送车市场发展机遇挖掘及行业投资坐标布局规划分析资料
- 2026Fast芯片组市场规模预测与增长驱动因素分析报告
- 2026生物制药行业融资模式与市场前景研判
- 2026中国新能源汽车零部件市场现状竞争分析及未来发展前景预测报告
- 2026中国工业母机数控系统自主化率提升与专精特新扶持
- 超声科住院医师规范化培训结业临床实践能力考核标准方案（2022版）
- 沉香与健康课件图片
- 财务资金管理培训
- 儿童碰伤应急处理
- 中建室外管网专项施工方案
- 污水处理PPP项目招标文件
- SYT 6378-2021 油水井取套回接工艺作法-PDF解密
- 监理抽检记录表格
- YY 0469-2023医用外科口罩
- 山西兰花科技创业股份有限公司大阳煤矿分公司煤炭资源开发利用、地质环境保护与土地复垦方案
- 中国越剧唱腔知到章节答案智慧树2023年浙江艺术职业学院
评论
0/150
提交评论