缩合反应练习题

第四章缩合反响练习题一、举例说明或解说以下人名反响。Mannich反响Strecker反响Michael反响Knoevenagel反响Perkin反响Stobbe反响Wttig反响Darzens反响Diels-Alder反响Aldol缩合二、请选出以下反响的主产物。1.ClCH2COOC2H5t-BuOK(t-BuOHA.ClCHCOOC2H5CHCOOC2H5CH2COOC2H5OHC.CHCH2OOC2H5Cl2.CHO浓NaOD/D2O(

O)()B.ClCHCOOCHCHOOCH522D.ClCHCOOOCHCOOC2H5)+()A.CH2OD+COOHB.CH2OH+COONaC.CH2OD+COONaD.CH2ONa+COONa3.(CH3)2CCHOH)CHO(A.(CH3)2CCHCH2CH2CCHCHOB.(CH3)2CCHCH2CHCCHCHOCH3OHCH3C.(CH3)2CCHCH2CH2CCHCOOHD.(CH3)2CCHCHCHCCHCHOCH3CH3O加热4.+O()OOOOOA.OB.OC.OD.OOOOOOO5.+(NaOEtCHONa)EtOHA.HCHOB.HCOOEtC.HOOCCOOHD.CO26.CH3(CH3CH2CO)2O()CHOCH3CH2COOK,加热A.H3CCHOB.H3CCH2COOHOCH3OHC.H3CCHCCOOHD.H3CCHCOOHCH3CH3O7.+CH2(COOC2H5)2C2H5ONa()C(COOC2H5)2OA.B.CH(COOC2H5)2OOC.D.CH(COOC2H5)2COCH2COOC2H58.CH3CH2COOHBr2)C2H5OH()(H+红P()OHZn,甲苯H3O+CHCOOC2H5CH3A.CH3CH2COBrCH3CHCOOC2H5OCH2CH3B.CH3CHCOOHCH3CHCOOC2H5OBrBrC.BrCH2CH2COOHCH3CHCOOHOCH2CH3D.CH3CH2CHOCH3CH2COOC2H5O9.COCH3+HCHO+HCl()NHAOH2BOHH2CCCN.HClCCH3.HClH2NCOHDOH2.HClCCCN.HClCCCH3H10.CHO+HCHOOH()HCHO()浓OH稀A.CH2OHCH2OHCHOCH2OHCHOCH2OHB.CHOCOOHC.CH2OHCOOHD.CH2CHOCH2OHOCH2OHCOOHCH2O11.Ph3P=CH2()CH2I2()过度ZnOCH2CH2A.B.CH2CH2CH2CH2C.D.OCH2OHNa2Cr2O7稀OH12.H2()()()NiH2SO4加热OHCOOHOHOOOOHA.B.OHOOOHOOC.D.O13.CH3CHCH2CH2CH2COOHH+)(OH加热AH2CCHCH2CH2CH2COOHBH3CHCCHCH2CH2COOHCODOOOCH3CHCH2CH2CH2COCCH2CH2CH2CHCH3OHOHCH3OH14.CH3COCl)AlCl3()(OOHOOCCH3OHOOCCH3CA.B.CH3OCH3OOHOOCCH3OCCH3OHC.OD.CCH3COCOCH3CH315.CHO+CH3CHO稀NaOH()OOOA.B.COHC.CH3D.CCHCHOOHOOOHCH316.HCOClNH3()Br2-NaOH()H2CCH3CH3CH3CH3A.HCONH2HCONHBrB.HCONH2HBrH2CH2CH2CH2CNH2CH3HCH2CH3CH3HCONHHCONH2HNH2C.2D.2H2CH2CH2CHCOO17.NHKOH(()N)OOOCH2BrOCH2OHOHOA.B.OHOOOOCH2OHCH2BrC.D.NHNKOOCOOEtC2H5ONa()稀NaOH-H2O()18.CH3COOH/H2OH3O+,加热OOOA.OHOOB.COOEtOOHC.OOHOOOD.OOHCHO+Ac2OCH3CO2K19.()OA.CH2COOHHOOCH2CCH2COOHB.CHCHCOOKC.D.OCHOOOCHOOCHOO20.+ClCH2COOEtt-BuOK()t-BuOHCOOEtClCOOEtCOOEtOHOCOOEtA.B.C.D.NOH2CCCCH3NaOAcH21.()H()()HH2O加热OCH3A.NCH3B.NCH3C.NCH3D.NO

CH3OCH2CH2CCH3CH3OCH2CH2CCH3NCH3OCH2CH2CCH3OCH3ONCH2CH2CCH3

CH3OOHCH3OCH2CH2CCH3OCH3OCH3OCH2CH2CCH3OH22.O(

)EtOH,H)SOCl2)((LiAlH4OCH2(COOEt)2EtONa

(

)OA.OOOB.OOOC.OOOD.OO23.PhMgBrOH3O()PhCHCH2OHOH

CH2OHCH2ClCH2OHCH2OHCH2OHCH2ClCH2OHCH2ClCH2OHCH2ClCH2OHCH2ClCH2OHCH2ClCH2OHCH2OHCl()PBr3(PPh3)CHONaOH()PhCHCH2BrPh3PCHCH2PhPhCCCCBrPPh3HHHHPh

COOEtCOOEtCOOEtCOOEtCOOEtCOOEtCOOEtB.PhCHCH2PhCHCH2BrPh3PCCH2PhH2CCCCBrBrHHHCH3CPhPhC.3PhCHCH3CH3CCPhCHCHOHBrPPh3HCHCHCH2PhD.PhCH2CH2OH22CHCH2PhPhCHCHBrPh3P24.+HCHO+(CH3)2NH()OHCH2N(CH3)2CH2N(CH3)2CH2N(CH3)2A.B.C.D.(H3C)2NH2CCH2N(CH3)2OHOHOHOHCOOCH325.+()H3CCOOCH3B.H3CCOOCH3H3CCOOCH3H3CCOOCH3A.C.D.H3CCH3H3CCH3H3CCH3H3CCH326.H+,加热()CH2CHCH(CH3)2OHA.CH2CHCH(CH3)B.CH2CH3C.CH32D.CH2CH2CH(CH3)2CHCH(CH)OHO27.CH3CH2CCl,AlCl3()CH3OHOOHOHOOCCH2CH3A.CB.C.D.CH2CH3CCH2CH3H2CCH2CH3CH3CH3OCH3COO28.NHKOH(BrCH2CH2CH2CH3())C2H5OHONaOH()+()H2OOOA.NKNCH2CH2CH2CH3COONaCH3CH2CH2CH2NH2COONaOOOOB.OKNHCH2CH2CH2CH3COONaCH3CH2CH2CH2NH2OKNHCH2CH2CH2CH3COONaOOOOOHONOHCOOHC.NHCH2CH2CH2CH3COOHCH3CH2CH2CNH2OOOOOD.ONHCH2CH2CH2CH3ONaCH3CH2CH2CH2NH2OCOOHCOONaOKOHH2CP(C6H5)329.+H2CCHCOCH3()