基础医学北大病理学课件 脑部肿瘤

Primaryintracranialtumor:

Glioma胶质瘤（40%）Meningioma脑膜瘤（15%）Acousticneurinoma听神经瘤（8%）Metastatictumors:lung,breast

§6Tumors分类发病率children:glioma,medulloblastoma

髓母细胞瘤医学课件园Primaryintracranialtumor:§61Size,location>natureLocaleffectGeneraleffect特点影响Biologic~histologicmalignancyInvasionMetastasistumor医学课件园Size,location>nature特点影响2Differentiation分化ClinicalprogressionGeneticchangesI.Astrocytoma星形细胞瘤AstrocytomaAnaplasticastrocytoma间变性-Glioblastomamultiforme多形性胶质母细胞瘤医学课件园I.AstrocytomaAstrocytoma医学课件3atypia,mitoticrate,capillary,endothelialcells,necrosis,hemorrhageAstrocytomaAnaplasticastrocytomaGlioblastomamultiformepoorlydefinedgray-whitesolidmultiform多形性:cyst,necrosis,hemorrhageAstrocytona病变医学课件园atypia,mitoticrate,Astrocyto4P53

mutation/lossofchr.17pLossofchr.22qRb

mutation/lossofchr.13qP16deletion/lossofchr.3pLossofchr.19qLossofch.10EGFRgeneamplificationGeneticchangesinastrocytomaNormalastrocyteAstrocytomaAnaplasticastrocytomaGlioblaxtomamultiforme医学课件园P53mutation/lossofchr.175astrocytoma医学课件园astrocytoma医学课件园6医学课件园医学课件园7Astrocytoma医学课件园Astrocytoma医学课件园www.yxkjy.co8Glioblatonamultiforme医学课件园Glioblatonamultiforme医学课件园ww9Giantcellsinglioblastomamultiforme医学课件园Giantcellsinglioblastomamu10Giantcellsinglioblastomamultiforme医学课件园Giantcellsinglioblastomamu11Giantcellsinglioblastomamultiforme,IHGFAP医学课件园Giantcellsinglioblastomamu12Pseudopalisading(glioblastomamultiforme)医学课件园Pseudopalisading(glioblastoma13Endothelialcellproliferationglioblastomamultiforme医学课件园Endothelialcellproliferation14<20yCerebellumPrimitiveundifferentiatedcellsmalltumorcells,scantycytoplasmrosette菊形团SeedingthroughCSFHighlymalignantII.Medulloblastoma

髓母细胞瘤医学课件园<20yII.Medulloblastoma医学课件15Medulloblastoma医学课件园Medulloblastoma医学课件园www.yxkj16医学课件园医学课件园17Seedingofmedulloblastoma医学课件园Seedingofmedulloblastoma医学课件18

From:arachnoidcell蛛网膜细胞

部位:~arachnoidgranulationdura硬脑膜

大体：solid,gritty砂粒样

光镜：whorl-likepatternpsammoma砂粒体Malignant:rareIII.Meningioma脑膜瘤医学课件园III.Meningioma脑膜瘤医学课件园www19meningioma医学课件园meningioma医学课件园20Hereisanotherbenignmeningiomabeneaththedura.Theseneoplasmsareslowgrowing,butmayreachalargesizebeforesymptomsleadtodetection.医学课件园Hereisanotherbenignmeningi21Meningiomaofsphenoidwing医学课件园Meningiomaofsphenoidwing医学课22医学课件园医学课件园23医学课件园医学课件园24医学课件园医学课件园25From:Schwanncell大体:encapsulated,solitary~nerves,spinalroots光镜:Spindletumorcells,

排列成束状，网状BenignIV.Neurilemmoma神经鞘瘤Schwannoma医学课件园From:SchwanncellIV.Neuril26Acousticschwannoma医学课件园Acousticschwannoma医学课件园www.y27Schwannomaofaspinalroot医学课件园Schwannomaofaspinalroot医学28Acousticschwannoma医学课件园Acousticschwannoma医学课件园www.y29Gemistocytixastrocytoma医学课件园Gemistocytixastrocytoma医学课件园30Gemistocytixastrocytoma医学课件园Gemistocytixastrocytoma医学课件园31Schwannoma医学课件园