Cytostatin-sodium-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemECytostatinsodiumCat.No.:HY-113612ACASNo.:457070-06-3分子式:C₂₁H₃₂NaO₇P分子量:450.44作用靶点:Apoptosis;Phosphatase作用通路:Apoptosis;MetabolicEnzyme/Protease储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性 Cytostatinsodium是一种有效的、选择性的蛋白磷酸酶2A(PP2A)抑制剂，IC50值为210nM。Cytostatinsodium具有抗转移特性和良好的抗肿瘤活性，并能诱导细胞凋亡(apoptosis)。Cytostatinsodium还能阻止B16黑色素瘤细胞与细胞外基质(层粘连蛋白和胶原蛋白)成分的粘附。Cytostatinsodium属于天然产物fosriecin家族[1][2][3][4]。IC50&Target IC50:210nM(PP2A)[1].REFERENCESBialyL,etal.Totalsynthesisandbiologicalevaluationoftheproteinphosphatase2Ainhibitorcytostatinandanalogues.Chemistry.2004;10(11):2759-2780.LawhornBG,etal.Totalsynthesisandevaluationofcytostatin,itsC10-C11diastereomers,andadditionalkeyanalogues:impactonPP2Ainhibition.JAmChemSoc.2006;128(51):16720-16732.KawadaM,etal.Cytostatin,aninhibitorofcelladhesiontoextracellularmatrix,selectivelyinhibitsproteinphosphatase2A.BiochimBiophysActa.1999;1452(2):209-217.KawadaM,etal.DifferentialinductionofapoptosisinB16melanomaandEL-4lymphomacellsbycytostatinandbactobolin.JpnJCancerRes.1999;90(2):219-225.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:021