Niraxostat-Y-700-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemENiraxostatCat.No.:HY-14669CASNo.:206884-98-2Synonyms:Y-700;Piraxostat分子式:C₁₆H₁₇N₃O₃分子量:299.32作用靶点:XanthineOxidase作用通路:MetabolicEnzyme/Protease储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Niraxostat(Y-700;Piraxostat)是一种口服有效的黄嘌呤氧化还原酶(XOR)抑制剂，可用于高尿酸血症和XOR可能涉及的其他疾病的研究。体内研究Niraxostat(Y-700;1mg/kg)hashighoralbioavailability(84.1%)andisalmostnotexcretedthroughthekidneys.Itismainlyeliminatedthroughtheliver[1].Niraxostat(Y-700;1-10mg/kg;oral;singledose)dose-dependentlyreducesplasmauratelevelsinoxonate-treatedrats[1].Niraxostat(Y-700;0.3-3mg/kg;Oral;Singledose)Innormalrats,dose-dependentlyreducesurinaryexcretionofurateandallantoinwhileincreasingexcretionofhypoxanthineandxanthine[1].PharmacokineticAnalysisofNiraxostat(Y-700)innormalrats[1]RouteDose(mg/kg)tmax(h)Cmax(μg/ml)AUC0-∞(μg/h/ml)t1/2(h)PO32.075.0PO13.2PO30.56.4930.312.7IV1/3.978.342.5REFERENCESFukunariA,etal.Y-700[1-[3-Cyano-4-(2,2-dimethylpropoxy)phenyl]-1H-pyrazole-4-carboxylicacid]:apotentxanthineoxidoreductaseinhibitorwithhepaticexcretion.JPharmacolExpTher.2004Nov;311(2):519-28.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax:021