Pantoprazole-sodium-Standard-BY1023-sodium-Standard-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEPantoprazolesodium(Standard)Cat.No.:HY-17507ARCASNo.:138786-67-1Synonyms:BY1023sodium(Standard);SKF96022sodium(Standard)分子式:C₁₆H₁₄F₂N₃NaO₄S分子量:405.35作用靶点:ProtonPump;Autophagy;Apoptosis;Bacterial作用通路:MembraneTransporter/IonChannel;Autophagy;Apoptosis;Anti-infection储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:≥100mg/mL(246.70mM)H2O:3.85mg/mL(9.50mM;Needultrasonic)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM2.4670mL12.3350mL24.6700mL5mM0.4934mL2.4670mL4.9340mL10mM0.2467mL1.2335mL2.4670mLBIOLOGICALACTIVITY生物活性Pantoprazole(sodium)(Standard)是Pantoprazole(sodium)的分析标准品。本产品用于研究及分析应用。Pantoprazolesodium(BY1023sodium)是一种具有口服活性的，有效质子泵(protonpump)抑制剂(PPI)。Pantoprazolesodium是一种取代的苯并咪唑，是一种有效的H+/K+-ATPase抑制剂，IC50为6.8μM。Pantoprazosodium可以改善pH值稳定性，并具有抗分泌，抗溃疡的作用。Pantoprazosodium联合阿霉素(Doxorubicin;HY-15142)可显着增加肿瘤生长延迟。1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEIC50&Target protonpumpREFERENCESKrupaJPatel,etal.Useoftheprotonpumpinhibitorpantoprazoletomodifythedistributionandactivityofdoxorubicin:apotentialstrategytoimprovethetherapyofsolidtumors.ClinCancerRes.2013Dec15;19(24):6766-76.HuaruiZhang,etal.Advancesinthediscoveryofexosomeinhibitorsincancer.JEnzymeInhibMedChem.2020Dec;35(1):1322-1330.WBeil,etal.Pantoprazole:anovelH+/K(+)-ATPaseinhibitorwithanimprovedpHstability.EurJPharmacol.1992Aug6;218(2-3):265-71.KTakeuchi,etal.Effectsofpantoprazole,anovelH+/K+-ATPaseinhibitor,onduodenalulcerogenicandhealingresponsesinrats:acomparativestudywithomeprazoleandlansoprazole.JGastroenterolHepatol.1999Mar;14(3):251-7.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-82