Rotigotine-Hydrochloride-Standard-N-0923-Hydrochloride-Standard-DataSheet-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemERotigotineHydrochloride(Standard)Cat.No.:HY-A0007RCASNo.:125572-93-2Synonyms:N-0923Hydrochloride(Standard)分子式:C₁₉H₂₆ClNOS分子量:351.93作用靶点:DopamineReceptor;AdrenergicReceptor;5-HTReceptor作用通路:GPCR/GProtein;NeuronalSignaling储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.溶解性数据体外实验DMSO:≥50mg/mL(142.07mM)H2O:4.76mg/mL(13.53mM;ultrasonicandwarmingandheatto60°C)*"≥"meanssoluble,butsaturationunknown.MassSolvent1mg5mg10mgConcentration制备储备液1mM2.8415mL14.2074mL28.4147mL5mM0.5683mL2.8415mL5.6829mL10mM0.2841mL1.4207mL2.8415mLBIOLOGICALACTIVITY生物活性Rotigotine(Hydrochloride)(Standard)是Rotigotine(Hydrochloride)的分析标准品。本产品用于研究及分析应用。RotigotineHydrochloride(N-0923Hydrochloride)是dopaminereceptor纯激动剂，是5-HT1Areceptor的部分激动剂，以及α2B-adrenergicreceptor的拮抗剂，Ki值分别为0.71nM(dopamineD3receptor)，4-15nM(D2，D5，D4receptors)，83nM(dopamineD1receptor)。IC50&TargetKi:0.71 nM(dopamineD3receptor),4-15 nM(dopamineD2,D5,D4receptors),83 nM(dopamineD1receptor)[1][2],176nM(α1A),273nM(α1B),338nM(α2A),27nM(α2B),30nM(5-HT1A),86nM(5-HT7)1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemE[2]REFERENCESWoodM,etal.RotigotineisapotentagonistatdopamineD1receptorsaswellasatdopamineD2andD3receptors.BrJPharmacol.2015Feb;172(4):1124-35.SchellerD,etal.Theinvitroreceptorprofileofrotigotine:anewagentforthetreatmentofParkinson'sdisease.NaunynSchmiedebergsArchPharmacol.2009Jan;379(1):73-86.FenuS,etal.Invivodopamineagonistpropertiesofrotigotine:RoleofD1andD2receptors.EurJPharmacol.2016Oct5;788:183-91.RadadK,etal.NeuroprotectiveeffectofrotigotineagainstcomplexIinhibitors,MPP?androtenone,inprimarymesencephaliccellculture.FoliaNeuropathol.2014;52(2):179-86.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400