Clevidipine-15N-d10-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEClevidipine-15N,d10Cat.No.:HY-17436S4分子式:C₂₁H₁₃D₁₀Cl₂₁₅NO₆分子量:467.37作用靶点:CalciumChannel;Isotope-LabeledCompounds作用通路:MembraneTransporter/IonChannel;NeuronalSignaling;Others储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Clevidipine-15N,d10是15N和氘代标记的Clevidipine(HY-17436)。Clevidipine是短效二氢吡啶钙离子通道拮抗剂，IC50为7.1nM。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs[1].REFERENCESYiX,VivienB,LynchC3rd.ClevidipineblockadeofL-typeCa2+currents:steady-stateandkineticelectrophysiologicalstudiesinguineapigventricularmyocytes.HurauxC,MakitaT,SzlamF,Thevasodilatoreffectsofclevidipineonhumaninternalmammaryartery.AnesthAnalg.1997Nov;85(5):1000-4.EricssonH,etal.Invitrohydrolysisrateandproteinbindingofclevidipine,anewultrashort-actingcalciumantagonistmetabolisedbyesterases,indifferentanimalspeciesandman.EurJPharmSci.1999Apr;8(1):29-37.EricssonH,etal.Pharmacokineticsofnewcalciumchannelantagonistclevidipineintherat,rabbit,anddogandpharmacokinetic/pharmacodynamicrelationshipinanesthetizeddogs.DrugMetabDispos.1999May;27(5):558-64.SchwielerJH,etal.Circulatoryeffectsandpharmacologyofclevidipine,anovelultrashortactingandvascularselectivecalciumantagonist,inhypertensivehumans.JCardiovascPharmacol.1999Aug;34(2):268-74.RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019Feb;53(2):211-216.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-8