Elsinochrome-A-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEElsinochromeACat.No.:HY-N10611CASNo.:24568-67-0分子式:C₃₀H₂₄O₁₀分子量:544.51作用靶点:ReactiveOxygenSpecies;Apoptosis;Autophagy;Fungal;FluorescentDye作用通路:Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB;Apoptosis;Autophagy;Anti-infection;Others储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性ElsinochromeA是一种苝醌光敏剂，在光激发下可产生活性氧(reactiveoxygenspecies)，诱导细胞凋亡(Apoptosis)和自噬(Autophagy)。ElsinochromeA还表现出针对白色念珠菌的抗真菌活性，通过光动力抗菌化疗(PACT)可去除白色念珠菌的生物膜。ElsinochromeA可用于光动力疗法(PDT)的研究(Ex:460nm)。体外研究ElsinochromeA(0-3μM,5min)reducessurvivalrate,inducesintracellularROSproduction,inducesformationofautophagosomesandinducesapoptosisunderlightilluminationinB16cells[1].ElsinochromeA(0.3-3μM,5min)islocatedinthemitochondriaoftheB16cells[1].ElsinochromeA(0-32μg/mL,24or48h)showsantifungalactivityagainstC.albicansafterirradiation[2].RT-PCR[1]CellLine:B16cellsConcentration:0.3-3μMIncubationTime:5minResult:Decreasedexpressionofatg2,atg9andatg10genes.Increasedexpressionofcaspase2,caspase9andtnfgenes.WesternBlotAnalysis[1]CellLine:B16cells1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEConcentration:0.3-3μMIncubationTime:5minResult:DecreasedexpressionofAtg5andCytCprotein.REFERENCESYaoY,etal.ElsinochromeAinducescellapoptosisandautophagyinphotodynamictherapy.JCellBiochem.2023Sep;124(9):1346-1365.PanL,etal.InhibitoryEffectsandMechanismofActionofElsinochromeAonCandidaalbicansandItsBiofilm.JFungi(Basel).2022Aug11;8(8):841.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;0