Ledipasvir-d6-hydrochloride-GS-5885-d-sub-6-sub-hydrochloride-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemELedipasvir-d6hydrochlorideCat.No.:HY-15602ASSynonyms:GS-5885-d6hydrochloride分⼦式:C₄₉H₄₉D₆ClF₂N₈O₆分⼦量:931.5作⽤靶点:HCV;Isotope-LabeledCompounds作⽤通路:Anti-infection;Others储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Ledipasvir-d6hydrochloride氘代标记的Ledipasviracetone(HY-15602A)。Ledipasviracetone(GS-5885acetone)Ledipasvir的活性活性分⼦成分。LedipasvirhepatitisCvirusNS5A的有效抑制剂，能够抑制GT1a和GT1b复制⼦活性，EC50值分别为34pM和4pM。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs[1].Ledipasviracetoneisconsideredtheactiveingredient,whichisconvertedtoLedipasvirspray-drieddispersion,anamorphousfreebase.REFERENCES[1].LinkJO,etal.Discoveryofledipasvir(GS-5885):apotent,once-dailyoralNS5AinhibitorforthetreatmentofhepatitisCvirusinfection.JMedChem.2014Mar13;57(5):2033-46.[2].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019Feb;53(2):211-216.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:0