人类疱疹病毒精美生物医学

人类疱疹病毒Containsseveralofthemostimportanthumanpathogens01Aspectrumofdiseases02Lifelongpersistentinfection03Periodicreactivation04Virion:spherical,150-200nmcore+capsid+envelopedsDNA,encodesatleast100proteins35proteinsstructureofvirusReplication:InthenucleusBudfromnuclearmembraneEarlyreplicationandlatereplication010203040506CPE:apartfromEBV,otherscancauseCPEincellcultureFormofinfectionReplicationinfection:primary,reactivatedLatentinfectionCongenitalinfection(先天性感染)Celltransformation病毒infectedcellsdiseasesHSV1粘膜上皮细胞／感觉神经节细胞多种疾病及潜伏感染HSV2粘膜上皮细胞／感觉神经节细胞生殖器疱疹及潜伏感染VZV皮肤细胞／脊髓后根神经节，颅神经的感觉神经节水痘／带状疱疹EBVB细胞，上皮细胞／B细胞传染性单核细胞增多症Burkitt瘤，鼻咽癌CMV上皮细胞，白细胞，精子细胞／分泌腺体多种疾病HHV6CD4+T细胞婴儿丘疹（唾液传播）免疫低下：持续急性感染HHV7CD4+T细胞幼儿皮疹（唾液传播）与其他疾病关系不清HHV8不清Kaposi肉瘤有关PropertiesTwoserotypes:HSV1andHSV2HSVgenome:encodesatleast70proteinssomeassociatedwithviralreplicationsomeenvelopeproteinsassociatedwithimmunereactionviralpenetrationHerpessimplexvirus（HSV）PathogenicitySourceofinfectionpatientsandcarriersRoutesoftransmissionHSV1：

contactHSV2：

sexually/maternalgenitalinfectionPathology:cytolyticinfection

Primaryinfectionmostareinapparent,butresultinantibodyproductionandlatentinfection010203040506HSV1Gingivitis(齿龈炎):mostfrequentlyKeratoconjunctivitis(角膜结膜炎)SkininfectionEncephalitisLatentinfection:inthetrigeminalganglia(三叉神经节)HSV2Genitalherpes:commonseenSkinherps:asHSV1Neonatalherpes:duringbirth,isaseverediseaseskin,eye,monthlesionencephalitismultipleorgandisseminated(多器官感染)Latentinfection：sacralganglia(骶神经节)Latentandrecurrenceinfection01virusreactivate,replication03peripheralsites,skinormucousmembrane05HSV1,HSV2neuron02axon(神经纤维)04HSV1：口唇部疱疹HSV2：genitalherpes06similarasHSVVZVnakedVZVenvelopedPathogenicitySourceofinfection：patientsRoutesofinfection:respiratorytractDisease：

水痘(Varicella/chickenpox)：儿童：斑丘疹，水疱，偶见并发症孕妇：症状较重，可致胎儿畸形，流产，死胎免疫低下：重症水痘

Latentinfectiondorsalrootganglia(脊髓后根神经节)Zoster(带状疱疹)SeeninadultsSeverepainandvesicle,ofteninchest020103

Cytomegalovirus(CMV)

巨细胞病毒Thelargest

geneticcontentofHHVVeryspeciesspecificandcellspecific(种属和细胞特异性)CharacteristicCPE:

multinucleatedcellsandintranuclearinclusionIsspreadcelltocellPathogenicitySourceofinfection:patients/inapparentpatientsRoutesofinfectionClosecontactMothertochildDiseasesNormalhostMostaresubclinicalMononucleosislikesyndrome(单核细胞增多症)amildillnessLatentinfectionImmunosuppressedhostMuchmoresevereDisseminatedpneumoniaInAIDS:胃肠炎，视网膜炎Congenitalandperinatedinfection先天和围产期感染MaybesevereFetalandnewbornCytomegalicinclusiondisease(巨细胞包涵体病)DeathoffetusC.N.Sdefect:耳聋，智力发育迟缓AnimportantpublicproblemViralantigensLatentphaseAgEBNA1:latentinfectionEBNA2:transformationofcellsLMP:latentinfectiontransformcellsReplicationAgEarlyAg:viralreplicationLateAg:structureproteins

PathogenecitySpearedbycontact:LatentinfectionPrimaryinfection:moreunapparentCelltransformationDiseasesInfectiousmononucleosisTransmittedbyinfectedsalivaMoreseeninadolescentsandyoungadultsFever,sorethroat,WBCincraesedDistinguishwithleukemiaheterophilagglutination(异嗜凝集试验)：heterophilAbcanagglutinate