艾滋病合并新型隐球菌脑膜炎文献回顾课件

获得性免疫缺陷综合征

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新型隐球菌脑膜脑炎主诉：头痛8天，复视4天，发热意识欠清1天头颅MRI：左侧半卵圆中心点状异常信号，T2Flair序列双顶叶皮层下点状略高信号（2016.4.27）入院后腰穿5.15.4潘式实验（1+）（1+）脑脊液RBC210*106/L420*106/L脑脊液WBC6*106/L2*106/L墨汁染色阳性阳性蛋白0.4g/L0.55g/L葡萄糖1.4mmol/L4.7mmol/L氯化物115mmol/L123mmol/L压力778mmH2O347mmH2O脑脊液细胞学—成团及散在带荚膜蓝染颗粒Wright-Giemsa染色放大倍数1：400脑脊液培养新生隐球菌报阳时间：48小时化验—白细胞计数及淋巴细胞计数AIDS确诊实验诊断新型隐球菌脑膜脑炎获得性免疫缺陷综合征ClinicalInfectiousDiseases2010;50:291–322ChinJMycol,April2010,Vol5,No2Cryptococcus/隐球菌

Incidence在免疫抑制患者中，隐球菌感染的发病率约为5%~10%，在AIDS患者中，隐球菌的感染率可以高达30%，而在免疫功能正常的人群中，隐球菌的感染率约为十万分之一左右ItisestimatedthattheglobalburdenofHIV-associatedcryptococcosisapproximates1millioncasesannuallyworldwide

ClinicalInfectiousDiseases2010;50:291–322ChinJMycol,April2010,Vol5,No2MortalityDespiteaccesstoadvancedmedicalcareandtheavailabilityofHAART,the3-monthmortalityrateduringmanagementofacutecryptococcalmeningoencephalitisapproximates20%Furthermore,withoutspecificantifungaltreatmentforcryptococcalmeningoencephalitisincertainHIV-infectedpopulations,mortalityratesof100%havebeenreportedwithin2weeksafterclinicalpresentationtohealthcarefacilities

ClinicalInfectiousDiseases2010;50:291–322临床表现ChinJMycol,April2010,Vol5,No2CSFinterpretationforthemanagementofpatientswithsuspectedencephalitisJournalofInfection(2012)64,347e373艾滋病合并新型隐球菌脑膜脑炎的影像学表现血管周围间隙扩大胶状假囊（治疗3个月后）RadiolPractice，sep2009，Vol24，N0.9V-R间隙（血管周围间隙）扩大血管周围间隙是与软脑膜下隙接续的,是软脑膜随着穿通动脉和流出静脉进出脑实质的延续而成扩大的V-R间隙意味着大量的隐球菌酵母细胞聚集于血管周围间隙或者部分阻滞了脑脊液的流出ClinicalInfectiousDiseases2010;50:291–322ChinJMycol,April2010,Vol5,No2ElevatedCSFPressureIftheCSFpressureis>25cmofCSFandtherearesymptomsofincreasedintracranialpressureduringinductiontherapy,relievebyCSFdrainage(bylumbarpuncture,reducetheopeningpressureby50%ifitisextremelyhighortoanormalpressureof<20cmofCSFIfthereispersistentpressureelevation>25cmofCSFandsymptoms,repeatlumbarpuncturedailyuntiltheCSFpressureandsymptomshavebeenstabilizedfor12daysandconsidertemporarypercutaneouslumbardrainsorventriculostomyforpersonswhorequirerepeateddailylumbarpuncturesPermanentVPshuntsshouldbeplacedonlyifthepatientisreceivingorhasreceivedappropriateantifungaltherapyandifmoreconservativemeasurestocontrolincreasedintracranialpressurehavefailed.Ifthepatientisreceivinganappropriateantifungalregimen,VPshuntscanbeplacedduringactiveinfectionandwithoutcompleteste