L-Histidinol-d3-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEL-Histidinol-d3Cat.No.:HY-W064342S分子式:C₆H₈D₃N₃O分子量:144.19作用靶点:Isotope-LabeledCompounds;EndogenousMetabolite;Aminoacyl-tRNASynthetase作用通路:Others;MetabolicEnzyme/Protease储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性L-Histidinol-d3((S)-2-Amino-3-(1H-imidazol-5-yl)propan-1-ol-d3)是氘标记的L-Histidinol(HY-W014233)。L-Histidinol?是一种口服活性的组氨酰-tRNA合成酶(histidyl-tRNAsynthetase)抑制剂。L-Histidinol干扰蛋白质合成的起始阶段，从而影响细胞增殖和代谢。L-Histidinol?具有调节肿瘤细胞对化疗试剂敏感性的作用。L-Histidinol?可降低一些化疗试剂对正常组织的毒性，并增强肿瘤细胞对化疗试剂的敏感性。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCESKohnoeS,etal.L-histidinolpotentiateshyperthermiccell-killingin-vitro.IntJOncol.1993Nov;3(5):835-9.WarringtonRC,etal.L-HistidinolinhibitsspecificallyandreversiblyproteinandribosomalRNAsynthesisinmouseLcells.JBiolChem.1977Aug10;252(15):5251-7.WarringtonRC,etal.EffectsofL-histidinolonthesusceptibilityofP815mastocytomacellstoselectedanticancerdrugsinvitroandinDBA/2Jmice.JNatlCancerInst.1987Jun;78(6):1177-83.WarringtonRC,etal.Reversalofthemultidrug-resistantphenotypeofChinesehamsterovarycellsbyL-histidinol.JNatlCancerInst.1989May10;81(10):798-803.WarringtonRC,etal.L-histidinolprotectionagainstcytotoxicactionofcytosinearabinosideand5-fluorouracilinculturedmousespleencells.JNatlCancerInst.1982Feb;68(2):279-86.ZaharkoD,etal.L-histidinol:preclinicaltherapeuticstudiesincombinationwithantitumoragentsandpharmacokineticstudiesinmice.CancerRes.1992Jul1;52(13):3604-9.StolfiRL,etal.ChemotherapeuticactivityofL-histidinolagainstspontaneous,autochthonousmurinebreasttumors.Chemotherapy.1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemE1990;36(6):435-40.BadaryOA.L-HistidinolattenuatesFanconisyndromeinducedbyifosfamideinrats.ExpNephrol.1999Jul-Aug;7(4):323-7.WarringtonRC,etal.L-histidinolimprovestheselectivityandefficacyofalkylatingagentsanddaunomycininmicewithP388leukaemia.BrJCancer.1989Nov;60(5):652-6.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forr