MAO-B-IN-49-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEMAO-B-IN-49Cat.No.:HY-178352CASNo.:3098883-91-8分子式:C₁₉H₂₀F₂N₂O₃分子量:362.37作用靶点:MonoamineOxidase;ReactiveOxygenSpecies(ROS)作用通路:NeuronalSignaling;Immunology/Inflammation;MetabolicEnzyme/Protease;NF-κB储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性MAO-B-IN-49是一种选择性，可逆的MAO-B抑制剂（对人MAO-B的IC50为1nM）。MAO-B-IN-49对MAO-B的选择性远高于对MAO-A的选择性(IC50=633.9)。MAO-B-IN-49可降低脂多糖(HY-D1056)(LPS)在HT22细胞中诱导的ROS产生。MAO-B-IN-49具有显著的神经保护作用，并能显著改善MPTP(HY-W114750)诱导的帕金森病(PD)小鼠模型的运动功能障碍。MAO-B-IN-49可用于帕金森病的研究[1]。体外研究MAO-B-IN-49(CompoundZM24)(2-50μM,24h)demonstratescellviabilityexceeding75%acrossalltestedconditionsinHT22cells[1].MAO-B-IN-49(5-20μM,24h)isco-incubatedwithcellsatdifferentconcentrations,andLipopolysaccharides(HY-D1056)(LPS)-inducedROSproductionissignificantlyreducedinHT22cells[1].CellViabilityAssayCellLine:HT22hippocampalneuronalcelllineConcentration:2μM,5μM,10μM,20μM,50μMIncubationTime:24hResult:Demonstratescellviabilityexceeding75%acrossalltestedconditions.体内研究MAO-B-IN-49(10mg/kg,30mg/kg,I.p.,oncedailyfor7days)significantlyimprovesMPTP-inducedmotordysfunction(includingmotoractivity,coordination,andmusclestrength)inParkinson'sdiseasemodelmice[1].1/2 MasterofBioactiveMolecules—您身边的抑制剂大师www.MedChemEAnimalModel:AParkinson'sdiseasemodelwasinducedinmaleC57BL/6Jmice(2monthsold,weighing20±2g)byinjectionoftheneurotoxinMPTP(1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)[1].Dosage:10mg/kg,30mg/kgAdministration:I.p.,30minsbeforeMPTP,oncedailyfor7daysResult:Ledtoanear-normalrestorationofmovementpatterns,indicatingasignificantimprovementinmotorfunction.Significantlyimprovedthemovementdisorderinmice.Effectivelyrelievedforelimbmuscleweaknessinmice.REFERENCESZhuM,etal.Design,synthesis,andbiologicalevaluationofhighlypotentandselectivehMAO-Binhibitorsfeaturingatetrahydrobenzo[f][1,4]oxazepinecore.EurJMedChem.2025Dec5;299:118080.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseo