雨课堂学堂在线学堂云《Drug Discovery in Prevention and Treatment of COVID-19（清华）》单元测试考核答案

第1题Whichoneofthefollowingbooksistheearliestmedicinebook?ATheYellowEmperor’sInnerClassic.BTheGrandCompendiumofMateriaMedica.CShenNong'sHerbalClassic.DMateriaMedicaArrangedAccordingtoPattern.第2题“Threeformulas

and

threemedicines”wereapprovedbyCFDAfortheCOVID-19indication.Choosethreeofthefollowingformulasbelongto“Threeformulas”.AQingfeiPaiduDecoction(清肺排毒汤)BHuashiBaiduformula(化湿败毒方)CXuanfeiBaiduformula(宣肺败毒方)DBuyangHuanwuDecoction(补阳还五汤)正确答案：ABC第3题“Threeformulas

and

threemedicines”wereapprovedbyCFDAfortheCOVID-19indication.Choosethreeofthefollowingmedicinesbelongto“Threemedicines”.AShuangHuangLianOralLiquid(双黄连口服液)BLianhuaQingwenCapsule(连花清瘟胶囊)CJinhuaQingganGranule(金花清感颗粒)DXueBiJingIntravenous(血必净注射液)正确答案：DCB第4题TherecoveryratewithTCMinCOVID-19treatmentinChinaismorethanA60%B70%C80%D90%第5题WhichoneisnotthecontentofQingfeiPaiduDecoction?AHuangQin(ScutellariaeRadix)BZeXie(AlismatisRhizoma)CChaiHu(BupleuriRadix)DHuangQi(AstragaliRadix)第6题InstituteforChineseMateriaMedica(ICMM)ofTsinghuauniversitywasformallyestablishedinA2016B2017C2018D2019第7题WhichstatementaboutISO/TC249isnotcorrect?AStandardizationinthefieldofmedicalsystemsderivedfromancientChinesemedicinewhichshallbeabletoshareonecommonsetofstandards.BInternationalorganizationforstandardization/traditionalChinesemedicinetechnicalcommittee.CThecommitteefocusesonqualityandsafetyofrawmaterials,manufacturedproductsandmedicaldevicesandofinformatics.DOnlytraditionalaspectsarecovered.第8题SkullcapherbismostprobablytakenfromAShanxiprovince.BShaanxiprovince.CHainanprovince.DGuangdongprovince.正确答案：AB第9题Whichapplicationofskullcapisnotcorrect?ATreatmentoffevercausedbytheflu.BReducesinflammation.CTreatmentofthereproductivesystemdiseases.DFightcancercells.第10题Whichoneofthefollowingcomponentsisthemarkerofskullcaps?ABaicalin.BWogonin.CScutellarein.DChrysin.第11题第1题WhatisthetargetofRemdesivir?ARdRpBSproteinCACE2DDNApolymerase第2题WhatwillbetheactiveformofRemdesivir?AalaninemetaboliteBmonophosphateCdiphosphateDtriphosphate第3题ChooseallthepotentialmechanismsofRibavirinAinhibitionofRNAreplicationBinhibitIMPDHCRNAmutagenesisDmodulateimmunesystem正确答案：DCBA第4题Whichoneistheadenineanalogue?ARemdesivirBFavipiravirCRibavirinDPenciclovir第5题Whichstatementaboutproteaseinhibitorisnotcorrect?APLproandMproaretwotypicalproteasethatcanbetargetedasthetherapeutictargetsforCOVID-19BDisulfiram,LopinavirandCamostatcanallbindtoPLproCDisulfiramworksasacompetitiveinhibitorforSARScoronavirusDDisulfiramworksasacompetitiveinhibitorforMERScoronavirus第6题Whatisnottheadvantageofvirus-targetinginhibitors?AveryspecificBlesstoxicCeasyforvirustogeneratemutantDbroadspectrum正确答案：CD第7题WhatisthedownstreamofdihydroorotatethatisinvolvedinRNAsynthesis?AorotateBUMPCUDPDUTP第8题WhereisDHODHinthecell?AcytosolBnucleusCmitochondriaDlysosome第9题Whichstatementiscorrect?AThalidomidecansuppressvirusreplication,overactivatedNF-ΚBandproinflammatorycytokinesBChloroquinecanreducetheproductionofpro-inflammatorycytokinesanddisruptviralSproteinCNiclosamidecaninhibitSKP2,enhanceautophagy,thereby,itcanstoptheMERS-CoVreplicationDCamostatandNafamostataretwoTMPRSS2inhibitorsthatcanblockcoronavirusspikeproteindrivenentryintothehostcell正确答案：DCBA第10题Whichmethodcouldfacilitatethediscoveryofnoveltargetsforcoronavirustreatment?AvirtualscreeningBmappingofprotein-proteininteractionCnucleotideanaloguesynthesisDvaccination第11题Lecture3homework第1题WhichisthefollowingAItechnologyisprimarilyusedinliteraturemining?()ANLPBBayesianNetworkCGameTheoryDTree-Search第2题Whattypeofdeeplearningalgorithmisbestformolecularpropertyprediction?()AGraph-CNNBRNNCGANDK-Means第3题Whichalgorithmisusedforgenomesequencealignmentandsimilarityranking?()ALSTMBEMCBLASTDKNN第4题WhichtargetoftheSARS-CoV-2isconservedatcatalyticalsitecomparedwithSARS-CoV?()ARdRpB3CLproCPLproDTransferase第5题WhichhumanreceptorissharedbetweenSARS-CoVandSARS-CoV-2?()AACE2BCLEC4MCCD209DCD147第6题WhattechnologyisusedinthecoursetosimulatetheinteractionbetweenSARS-CoV-2anditshumanreceptor?()AMMBQMCDFTDMD第7题Whichtypeofstatisticalmeasurementwasusedinthecoursetomeasuretheperformanceofligand-basedAIpredictionmodels?()AaccuracyBAUCCcorrelationcoefficientDR^2第8题Whichcompoundlibrarycanbeusedfordrugrepurposing?()AFDAapprovedlibraryBCommercialcompoundLibrariesCVirtualhypotheticalcompoundlibrariesDPubChemlibrary第9题Whatisthemainpurposeoftheproject“NextStrain”?()APredictthelocationofthenextoutbreakBPredictthegenomesequenceofthenextoutbreakCTracktimeandlocationsofSARS-CoV-2mutationsDPredictthetimeofthenextoutbreak第10题WhichofthefollowisNOTanadvantageofcurrentAItechnologyinDrugDiscovery?()AFastanalysisBBroadKnowledgeCObjectivejudgementDGeneratingHypothesis第11题第12题Lecture4homework第1题Howmanypathwaysarethereforcoronavirustoenterthehostcell?A1B2C3D4第2题Whatproteinsareusedtocleavepolyproteinstoproducenonstructuredproteins?ARdRpB3CLproteaseCPLproteaseDHelicase正确答案：BC第3题Whatapproachcanbeusedforidentificationofnewchemicalhits?ATargetidentificationBPK/PDpredictionCVirtualscreeningDADMETprediction第4题Whatcontributestoprotein-ligandinteraction?AHydrogenbondBhydrophobicinteractionCwaterreleaseDproteinsize正确答案：ABC第5题Whichbindingmodelindicatesprotein/receptorisrigid?ALock-keyBInduced-fitCConformationselectionDAllostericmodel第6题Whichfactorsareimportantinthesuccessofvirtualscreening?ALargeandDiversecompoundlibraryBproteinsizeCscoringaccuracyDwatermodel正确答案：AC第7题WhichonesareNOTcorrectregardinghomologymodeling?AHomologymodelingisatemplate-freemethodforstructurepredictionBItisstillchallengingtopredictthestructureforhardtargetsCHomologymodelcanbedirectlyusedforstructure-baseddrugdesignwithoutevaluationorrefinementDHomologymodelingrepliesonthegrowthofknownstructures正确答案：AC第8题WhichoneisNOTcorrectregardingSARS-CoV-23CLprotease?AItisattractivetargetduetotheexistenceofviralproteaseinhibitorsdevelopedforHIVandothervirusesBItisaserineproteaseCDimerconformationisneededforthein-silicomodelingagainstthistargetDThehomologymodelbasedontheSARS-CoV3CLproisreliableforrealapplication第9题WhatstrategyisNOTusedinthevirtualscreeningagainst3CLprotease?AEnsembledockingBforce-fieldbasedrescoringCMDsimulationDshapescreening第10题Whatareimportantfordesigningcovalentinhibitors?ASelectivewarheadBmicrosomestabilityCpeptide-likeDsolubility正确答案：DBALecture5homework第1题Whichofthefollowingarebiologics?

AOligonucleotidesBInsulinCPenicillinDEngineeredcells正确答案：DBA第2题Whichdescriptionaboutbiologicsiswrong?ABiologicscannotdiffusethroughthecellmembraneBBiologicscommonlyhavelargermolecularweightthanchemicaldrugsCBiologicsaremostlyadministeredbyinjectionDBiologicscanaccessanytherapeutictarget第3题WhatreceptoronhumancellsdirectlybindstoSARS-CoV-2?AADAM17BACE2CSpikeproteinDDPP4第4题ScientistaredevelopingtherapeuticantibodiesagainstwhichoftheSARS-CoV-2protein?ARNApolymeraseBProteaseCSpikeproteinDNucleoprotein第5题Whatpropertyisthemostcriticalforthetherapeuticanti-SARS-CoV-2antibody?

AHighstabilityBLongcirculationtimeCBindingtoSproteinDNeutralizingtheSARS-CoV-2virus第6题Whichmethod(s)areusedtodeveloptherapeuticanti-SARS-CoV-2antibody?AConvalescentplasmatherapyBScreeningforcross-reactivityinexistinganti-SARS-CoV-1antibodyCPhagedisplaytechnologyDSortingpatientBcellsandsingleBcellcloning正确答案：DCB第7题Whichdescription(s)aboutimmunomodulatoryantibodiesis/areincorrect?AImmunomodulatoryantibodiesblockthevirusentryinlungepithelialcellsBImmunomodulatoryantibodiessuppresstheimmunereactiontoSARS-CoV-2CImmunomodulatoryantibodiessynergizewithanti-viraltreatmentDTocilizumab(Actemra®)andsarilumab(Kevzara®)wereoriginallydevelopedforSARS正确答案：DA第8题WhattargetsareunderinvestigationtomanagetheimmunereactioninCOVID-19?AIL-6RBIL-6CGM-CSFDCCR5正确答案：DCBA第9题第10题第11题Lecture6homework第1题What

does

the

Red

Queen

hypothesis

tell

usintermsoftherelationshipbetweenhumanandvirus?

()AHuman

have

to

fight

against

virusBViruses

are

undefeatableCBoth

virus

and

their

host

arecontinuously

evolvedDVirus

and

their

host

remain

the

same第2题Whichis

the

first

step

of

the

virus

life

circle?

()Athe

release

of

new

virus

particlesBthebindingbetweentheSproteinandtheACE2receptorCthe

endocytosis

of

virus

particleDthe

translation

of

new

virus

protein第3题WhichinthefollowingdoesNOTbelongtotheinnateimmunity?()ABlymphocytes(Bcells)BPhagocyticcellsCInterferonDNaturalkillercells第4题Whichdescriptionaboutinterferoniscorrect?()AInterferonishostspecificaswellasvirusspecificBItcannotbeproducedbyvirtuallyanycellCTherearefourtypesofinterferon(IFN)knownsofarDInterferonisthefirstlineofdefenseagainstvirusesbeforeaspecificinmuuneresponseismounted第5题WhichtargetCANNOTactivateNaturalkiller()cells?()AAntibodycoatedcellsBCellsinfectedbyvirusesandsomeintracellularbacteriaCTcellsDCellslackingclassIMHCmolecules第6题WhatpercentageofhumangenomesincludingEndogenousRetrovirus()?()AAbout8%ofhumangenomeBAbout18%ofhumangenomeCAbout28%ofhumangenomeDAbout38%ofhumangenome第7题MHCClassIImoleculespresentpeptidesmadeoutsidethecellto()ACD8+helperTcellsBCD4+helperTcellsCCD8+CD4cellsDHelperTcells第8题MHCClassImoleculespresentpeptidesmadeinsidethecellto()ACD8+helperTcellsBCD4+helperTcellsCCD8+cytotoxicTcellsDCD4+cytotoxicTcells第9题Antiviraltherapycantargetthefollowingaspectsexcept().AVirusitselfBHostcellmetabolismCHostimmunesystemDAntibodiesinhosts第10题Whichresponseorcellisnotincludedininnateimmuneresponses?()ATcellresponsesBPhagocytosisCInterferonsDNKcells第11题第12题第13题WhatpercentageofhumangenomesincludingEndogenousRetrovirus(ERV)?()AAbout8%ofhumangenomeBAbout18%ofhumangenomeCAbout28%ofhumangenomeDAbout38%ofhumangenomeLecture7homework第1题WhichisnotthereasonforeffectivetrackingoftheCOVID-19spreadinglately?AThemassivenucleic-acidtestingwaspossibleBPositivesampleswerefoundinchopboardCPeoplehavegotexperiencesincontainingthevirusDTherewerelessconfirmedcases第2题Whichdescriptionaboutvirusiswrong?AVirusgenerallyhasanoutsideshellmadeofproteinBViruscancarryproteaseinsideCViruscanproliferateonitsownDSurfaceproteincanservethefunctionfordockingontoitshost第3题3Whichmethodcouldbeusedtoquicklyconfirmthesuccessfulcollectionofanunknownpathogenbeforenucleicacidsequencing?APhysicalmeasurementBCytopathiceffectCDetectionofproteinsDDetectionofgeneticmaterials第4题Whyantibodiesareusuallypreferredtotargetproteinsforquickat-home