ASF-006-sodium-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEASF-006sodiumCat.No.:HY-179634分⼦式:C₁₂₅H₈₀N₈Na₂₀O₄₈分⼦量:2921.79作⽤靶点:SARS-CoV;HIV;Enterovirus;Angiotensin-convertingEnzyme(ACE);RSV;Filovirus作⽤通路:Anti-infection;MetabolicEnzyme/Protease储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性ASF-006sodium⼀种四⾜⾊氨酸衍⽣物，⼀种有效的病毒⼊侵(viralinvasion)抑制剂。ASF-006sodium对多种SARS-CoV-2Omicron变体均表现出强效抗病毒活性，但对SARS-CoV-2祖先毒株(武汉-Hu-1)⽆效。ASF-006sodium通过变构机制竞争性抑制受体结合域(RBD)与ACE2的结合。ASF-006sodium对OmicronBA.1、OmicronXBB.1.5、呼吸道合胞病毒(RSV)和埃博拉病毒(Ebolavirus)的感染抑制作⽤的IC50值分别为0.02μM、0.3μM、1.52μM和0.2μM。ASF-006sodium抑制HIV和肠道病毒A71的细胞⼊侵。体外研究ASF-006sodium(20μM)showsstronginhibitionofinfectionbyVSVpseudotyped,displayingOmicronBA.2orBA.4/5subvariantsonitssurfaceintheabsenceofsignificanttoxicitytocells[1].ASF-006sodiumagainstdifferentSARS-CoV-2Omicronvariantsbutalsohighlightitslimitedactivityagainstmoreancestralstrains(Wuhan-Hu-1)ordistantcoronaviruses(SARS-CoV)[1].ASF-006sodiumshowsstrongantiviralactivityagainstRSV-A,withIC50valuesrangingbetween0.05and0.2μMwheninfectingA549,HEp-2,orVerocells[1].ASF-006sodiumshowsnoantiviralactivityagainstVSV(Rhabdoviridae),Nipahvirus,orSindbisvirus[1].ASF-006sodiuminteractswiththeSprotein,interferingwithbindingtoitscellularreceptorACE2[1].ASF-006sodiumbindstoRBDBA.1andSBA.1proteinswithKdvaluesof-60μMand5μM,respectively[1].体内研究ASF-006sodium(100mg/kg,intranasal,oncedailyfor3days)reducesviralloadinamurinemodelofSARS-CoV-2OmicronBA.1infection[1].AnimalModel:K18-hACE2(geneticallymodifiedtoexpresshumanACE2underthecontrolofthehumancytokeratin18promoter;6-week-old)wereinfectedwithSARS-CoV-2OmicronBA.1[1]1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEDosage:100mg/kg(50μL)Administration:Intranasal;oncedaily;3daysResult:Asignificant>3.5-foldreductioninviralloadwasobservedinthelungsoftreatedmicecomparedtothevehiclegroup,asdeterminedbyquantitativeRT-PCR.Nosignsofdrugtoxicitywereobserved.REFERENCES[1].Martí-MaríO,etal.ATetrapodalTryptophanDerivativewithMultipleExposedFreeCarboxylicAcidsBlocksHostCellEntryofOmicronSARS-Cov-2andRespiratorySyncytialVirus.ACSOmega.2025;10(46):56830-56844.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.For