11β-HSD1-IN-25-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE11β-HSD1-IN-25Cat.No.:HY-180549CASNo.:1261266-23-2分⼦式:C₂₁H₁₂F₈O分⼦量:432.31作⽤靶点:11β-HSD;AMPK作⽤通路:MetabolicEnzyme/Protease;Epigenetics;PI3K/Akt/mTOR储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性11β-HSD1-IN-25⼀种选择性且⼝服有效的11β-HSD1抑制剂。11β-HSD1-IN-25能有效降低体外及⾎清中的糖⽪质激素⽔平，并在体外和体内模型中减少脂质积累。11β-HSD1-IN-25通过双重机制调节脂质代谢：抑制11β-HSD1以及激活AMP活化蛋⽩激酶(AMPK)信号通路。11β-HSD1-IN-25可⽤于体内肥胖及相关代谢紊乱的研究[1]。体外研究11β-HSD1-IN-25(10μM)suppresses11β-HSD1toamelioratelipidmetabolicdisordersandreduceslipidaccumulationin3T3-L1adipocytes[1].体内研究11β-HSD1-IN-25(0.5mg/kg,p.o.,dailyfor60days)alleviatesobesity,reducesthesizeofadipocytesinadiposetissue,suppresses11β-HSD1toameliorateadiposetissuelipidmetabolicdisorders,amelioratesadipocytehypertrophyandinflammationin11β-HSD1lentivirusinduced(ornot)-maleC57BL/6mice[1].AnimalModel:11β-HSD1lentivirusinduced(ornot)(i.v.)-maleC57BL/6mice(8weeks,20-22g)[1]Dosage:0.5mg/kgAdministration:p.o.,dailyfor60daysResult:Significantlymitigatedweightgainwheninducedby11β-HSD1lentivirus.Significantlyreducedserumconcentrationsofcorticosterone(CORT),cholesterol(CHO),triglycerides(TG),low-densitylipoprotein(LDL),andhighdensitylipoprotein(HDL).Improvedadipocytemorphology.Decreased11β-HSD1proteinexpression.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEExhibitedasubstantialincreaseintheproteinexpressionlevelsofUCP1,thep-AMPK/AMPKratio,andCPT1whenreducedby11β-HSD1lentiviruswhenreducedby11β-HSD1lentivirus.ShowedasignificantreductioninthemRNAexpressionofHsd11b1,Srebp1c,Fas,andAcc1andexhibitedaincreaseintheexpressionlevelsofCpt1,Ucp1,andHslwhenreducedby11β-HSD1lentivirus.NotexhibitedasignificantelevationinFASproteinexpressioninadiposetissuewhennotreducedby11β-HSD1lentivirus.ResultedinasubstantialreductioninFASproteinexpression.UpregulatedHSLproteinnomatterreducedby11β-HSD1lentivirusornot.SignificantlyreducedF4/80proteinexpressioninadiposetissue.REFERENCES[1].HanY,etal.11β-HSD1inhibitoralleviateslipidmetabolismdisorderbyactivatingtheAMPKsignalingpathway.SciRep.2025Nov25;15(1):41968.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forrese