Belinostat-d5-PXD101-d-sub-5-sub-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEBelinostat-d5Cat.No.:HY-10225SCASNo.:2130852-65-0Synonyms:PXD101-d5;PX105684-d5分⼦式:C₁₅H₉D₅N₂O₄S分⼦量:323.38作⽤靶点:Isotope-LabeledCompounds;Autophagy;HDAC作⽤通路:Others;Autophagy;CellCycle/DNADamage;Epigenetics储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Belinostat-d5(PXD101-d5)氘代标记的Belinostat(HY-10225)。Belinostat(PXD101;PX105684)⼀种有效的HDAC抑制剂，在HeLa细胞提取物中的IC50为27nM。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].PlumbJA,etal.PharmacodynamicresponseandinhibitionofgrowthofhumantumorxenograftsbythenovelhistonedeacetylaseinhibitorPXD101.MolCancerTher.2003Aug;2(8):721-8.[2].QianX,etal.ActivityofPXD101,ahistonedeacetylaseinhibitor,inpreclinicalovariancancerstudies.MolCancerTher.2006Aug;5(8):2086-95.[3].ChiaS,etal.Phenotype-drivenprecisiononcologyasaguideforclinicaldecisionsonepatientatatime.NatCommun.2017Sep5;8(1):435.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:02