Clausenidin-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEClausenidinCat.No.:HY-N16771CASNo.:28384-44-3分⼦式:C₁₉H₂₀O₅分⼦量:328.36作⽤靶点:Caspase;Apoptosis;Bcl-2Family;Bacterial;VEGFR作⽤通路:Apoptosis;Anti-infection;ProteinTyrosineKinase/RTK储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Clausenidin⼀种靶向凋亡(apoptosis)相关通路(包括线粒体通路和死亡受体通路)及⾎管内⽪⽣长因⼦(VEGF)的选择性抑制剂。Clausenidin通过激活caspase-3、caspase-8和caspase-9，上调促凋亡蛋⽩Bax并下调抗凋亡蛋⽩Bcl-2，诱导线粒体膜去极化。Clausenidin同时抑制VEGF表达阻断⾎管⽣成，发挥抗肿瘤活性。Clausenidin对结核分枝杆具有抑制作⽤(MIC=200μg/mL)。Clausenidin可诱导肝癌细胞凋亡、阻滞细胞周期于G2/M期并抑制肿瘤⾎管⽣成。Clausenidin可⽤于肝癌等恶性肿瘤的研究。IC50&TargetCaspase3Caspase-8Caspase-9体外研究ClausenidinagainstHepG2livercancercellswithanIC50of7.7μg/mL[1].REFERENCES[1].WaziriPM,etal.ClausenidinInducesCaspase8-DependentApoptosisandSuppressesProductionofVEGFinLiverCancerCells.AsianPacJCancerPrev.2018Apr25;19(4):917-922.[2].WaziriPM,etal.ClausenidinfromClausenaexcavatainducesapoptosisinhepG2cellsviathemitochondrialpathway.JEthnopharmacol.2016Dec24;194:549-558.[3].SunthitikawinsakulA,etal.CoumarinsandcarbazolesfromClausenaexcavataexhibitedantimycobacterialandantifungalactivities.PlantaMed.2003Feb;69(2):155-7.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:0