Discodermolide-NVP-XAA-296-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEDiscodermolideCat.No.:HY-105409CASNo.:127943-53-7Synonyms:NVP-XAA-296;XAA296分⼦式:C₃₃H₅₅NO₈分⼦量:593.79作⽤靶点:Microtubule/Tubulin;Apoptosis作⽤通路:CellCycle/DNADamage;Cytoskeleton;Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Discodermolide(NVP-XAA-296)⼀种强效的微管(microtubule)稳定剂，其Ki值为0.4μM。Discodermolide能够稳定微管，诱导G2期或M期细胞周期阻滞和细胞凋亡(apoptosis)，从⽽抑制癌细胞增殖。Discodermolide可竞争性抑制Paclitaxel(HY-B0015)与微管蛋⽩聚合物的结合，并抑制Paclitaxel耐药细胞的⽣长。Discodermolide可⽤于乳腺癌和结肠癌的研究[1][2][3]。REFERENCES[1].AltmannKH.Microtubule-stabilizingagents:agrowingclassofimportantanticancerdrugs.CurrOpinChemBiol.2001Aug;5(4):424-31.[2].KowalskiRJ,etal.Themicrotubule-stabilizingagentdiscodermolidecompetitivelyinhibitsthebindingofpaclitaxel(Taxol)totubulinpolymers,enhancestubulinnucleationreactionsmorepotentlythanpaclitaxel,andinhibitsthegrowthofpaclitaxel-resistantcells.MolPharmacol.1997Oct;52(4):613-22.[3].HungDT,etal.(+)-Discodermolidebindstomicrotubulesinstoichiometricratiototubulindimers,blockstaxolbindingandresultsinmitoticarrest.ChemBiol.1996Apr;3(4):287-93.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-