Galectin-3-IN-7-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEGalectin-3-IN-7Cat.No.:HY-179410分⼦式:C₃₁H₃₄FN₅O₁₁S分⼦量:703.69作⽤靶点:Galectin作⽤通路:Immunology/Inflammation储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Galectin-3-IN-7⼀种选择性的Galectin-3抑制剂，其Kd值为5.7nM，对Gal-1的选择性⾼390倍。Galectin-3-IN-7可下调TGFβ刺激的LX2肝状细胞中促纤维化信号通路，如ACTA2、COL1A2和FN1。Galectin-3-IN-7可⽤于纤维化研究。IC50&TargetGalectin-35.7nM(Kd)体外研究Galectin-3-IN-7(Compound11)exhibitsmoderateplasmaproteinbindingratesof45%,43%,and90%inhuman,mouse,andratplasmarespectively[1].Galectin-3-IN-7(3.7-300μM,24h)showsaCC50of>300μMagainstHEK293,HepG2,THP-1,JurkatE6.1andLX2cells[1].Galectin-3-IN-7(3.7-300μM,24h)doesnotsignificantlyinhibitLPS(HY-D1056)-inducedTNFαsecretioninTHP-1macrophage-likecells[1].Galectin-3-IN-7(3.7-300μM,48h)dose-dependentlydownregulatesthemRNAexpressionofACTA2,COL1A2,andFN1inTGFβ1-stimulatedLX2cells[1].RealTimeqPCR[1]CellLine:LX2cellsConcentration:3.7,11.1,33.3,100and300μMIncubationTime:48hResult:ReducedthemRNAexpressionofACTA2,COL1A2,andFN1.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEREFERENCES[1].ZýkaJ,etal.N-Aryl-N-LactosylamidesasPotentandHighlySelectiveInhibitorsofGalectin-3withAntifibroticActivity.JMedChem.2025;68(22):24624-24648.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792