Indole-4-carboxaldehyde-13C-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEIndole-4-carboxaldehyde-13CCat.No.:HY-W001288S分⼦式:C₈₁₃CH₇NO分⼦量:146.15作⽤靶点:Isotope-LabeledCompounds;NF-κB作⽤通路:Others;NF-κB储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Indole-4-carboxaldehyde-13C13C标记的Indole-4-carboxaldehyde(HY-W001288)。Indole-4-carboxaldehyde⼀种麦⾓⽣物碱前体。Indole-4-carboxaldehyde可通过激活NF-κB，减弱甲⼄⼆醛(MGO)诱导的炎症相关因(如TNF-α和IFN-γ)的表达，且对HepG2细胞⽆毒性。Indole-4-carboxaldehyde可降低MGO诱导的晚期糖化终产物(AGE)⽣成及其受体(RAGE)的表达。Indole-4-carboxaldehyde可⽤于肝脂变性的研究。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].ChaSH,etal.Indole-4-carboxaldehydeIsolatedfromSeaweed,Sargassumthunbergii,AttenuatesMethylglyoxal-InducedHepaticInflammation.MarDrugs.2019Aug21;17(9):486.[2].AlanP.Kozikowski,etal.Newsynthesisandsomeselectedreactionsofthepotentialergotalkaloidprecursorindole-4-carboxaldehyde.J.Org.Chem.1980,45,16,3350-3352.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021-