Ko-143-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemEKo143(Standard)Cat.No.:HY-10010RCASNo.:461054-93-3分子式:C₂₆H₃₅N₃O₅分子量:469.57作用靶点:BCRP;ReferenceStandards作用通路:MembraneTransporter/IonChannel;Others储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性Ko143(Standard)是Ko143(HY-10010)的分析标准品。本产品用于研究及分析应用。Ko143是有效且选择性的ATP结合盒亚家族G成员2(ABCG2/BCRP)抑制剂。Ko143比P-gp和MRP-1运输蛋白高出200倍的选择性。IC50&TargetEC90:26nM(BCRP)REFERENCESWeidnerLD,etal.TheInhibitorKo143IsNotSpecificforABCG2.JPharmacolExpTher.2015Sep;354(3):384-93.JDAllenetal.PotentandSpecificInhibitionoftheBreastCancerResistanceProteinMultidrugTransporterinVitroandinMouseIntestinebyaNovelAnalogueofFumitremorginC.Mol.CancerTher.2002,1,417-425.WenJH,etal.EffectofUrsolicAcidonBreastCancerResistanceProtein-mediatedTransportofZD4522InVivoandVitro.ChinMedSciJ.2015Dec;30(4):218-25.HouJ,etal.Quantitativedeterminationandpharmacokineticstudyofthenovelanti-Parkinson'sdiseasecandidatedrugFLZinratbrainbyhighperformanceliquidchromatography-tandemmassspectrometry.JPharmBiomedAnal.2012Jul;66:232-9.LiuK,etal.MetabolismofKO143,anABCG2inhibitor.DrugMetabPharmacokinet.2017Aug;32(4):193-200.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792Fax: