Lys-PEG1-Dasa-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemELys-PEG1-DasaCat.No.:HY-180963分⼦式:C₃₃H₄₇ClN₁₀O₅S分⼦量:731.31作⽤靶点:PROTACs;Bcr-Abl作⽤通路:PROTAC;ProteinTyrosineKinase/RTK储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Lys-PEG1-Dasa⼀种靶向BCR-ABL的PROTAC降解剂，其在K562细胞中的DC50为0.98nM。Lys-PEG1-Dasa对K562细胞具有增殖抑制活性，对应的IC50为0.4569nM。Lys-PEG1-Dasa可⽤于慢性粒细胞⽩⾎病的相关研究[1][2]。体外研究Lys-PEG1-Dasa(0-2.5nM,0-48h)efficientlydownregulatesBCR-ABLandexertspotentantiproliferativeactivityinK562cells[1].CellCytotoxicityAssay[1]CellLine:K562cellsConcentration:0,0.01,0.1,0.25,0.5,0.75,1and2.5nMIncubationTime:48hResult:ExertedpotentantiproliferativeactivitywithIC50=0.4569nMWesternBlotAnalysis[1]CellLine:K562cellsConcentration:0,0.5,1,2.5and5nMIncubationTime:0,12,24,36and48hResult:EfficientlydownregulatedBCR-ABLproteinexpressionwithDC50=0.4790nM,Dmax=1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE99.1%at5nM.REFERENCES[1].ChenX,etal.Mightymini-PROTACs:anemergingclassofdegraders.EurJMedChem.2026Jan5;301:118202.[2].ZhangJ,etal.Singleaminoacid-basedPROTACstriggerdegradationoftheoncogenickinaseBCR-ABLinchronicmyeloidleukemia(CML).JBiolChem.2023Aug;299(8):104994.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: