MPXV-p37-protein-IN-1-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMPXVp37protein-IN-1Cat.No.:HY-180228CASNo.:3096845-40-5分⼦式:C₁₈H₁₅F₂N₃O₂S分⼦量:375.39作⽤靶点:Orthopoxvirus作⽤通路:Anti-infection储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性MPXVp37protein-IN-1⼀种强效且⼝服有效的猴痘病毒(MPXV)p37蛋⽩抑制剂。MPXVp37protein-IN-1对MPXV具有显著的抗病毒活性，EC50值为12.14nM，且细胞毒性低(CC50=304.63μM)。MPXVp37protein-IN-1在⼩⿏体内表现出低毒性和良好的耐受性。MPXVp37protein-IN-1可⽤于抗猴痘病毒药物的研究[1]。IC50&TargetMPXV12.14nM(EC50)体外研究MPXVp37protein-IN-1(compoundC12)(1-10μM,48h)demonstratespotentantiviralactivityagainstMPXVinVerocells[1].MPXVp37protein-IN-1formscriticalhydrogenbondswithresiduesTYR258andSER292,whichlikelycontributetoitsenhancedbindingaffinityandantiviralpotency[1].体内研究MPXVp37protein-IN-1(compoundC12)(2000mg/kg,p.o.,singledose)iswelltoleratedinCD-1mice[1].MPXVp37protein-IN-1(100mg/kg,p.o.,dailyfor14days)iswelltoleratedinCD-1mice[1].AnimalModel:CD-1mice[1]Dosage:2000mg/kgAdministration:p.o.,singledoseResult:Showednotoxicity,abnormalweightgain,orgrosspathologicalchangesinmajororgans1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE(lungs,intestines,kidneys,spleen).AnimalModel:CD-1mice[1]Dosage:100mg/kgAdministration:p.o.,dailyfor14daysResult:Showednoabnormalweightchanges,visiblelesions,orhistopathologicalalterationsinmice.REFERENCES[1].ChenY,etal.Ligand-baseddesignandoptimizationoftecovirimatderivativesaspotentantiviralagentsagainstmonkeypoxvirus.EurJMedChem.2026;303:118447.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;02