Murrayafoline-A-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEMurrayafolineA(Standard)Cat.No.:HY-W100287RCASNo.:4532-33-6分⼦式:C₁₄H₁₃NO分⼦量:211.26作⽤靶点:NF-κB;ReferenceStandards;p38MAPK;InterleukinRelated;IKK;JNK;β-catenin;Wnt作⽤通路:NF-κB;Others;MAPK/ERKPathway;Immunology/Inflammation;StemCell/Wnt储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性MurrayafolineA(Standard)MurrayafolineA(HY-W100287)的分析标准品。本产品⽤于研究及分析应⽤。MurrayafolineA⼀种可以从Murrayatetramera中提取的咔唑类⽣物碱。MurrayafolineA直接靶向特异性蛋⽩1(Sp1)，从⽽抑制NF-κB和MAPK信号通路。MurrayafolineA在⾎⼩板衍⽣⽣长因⼦(PDGF)刺激的⾎管平REFERENCES[1].LiCH,etal.NaturalcarbazolealkaloidmurrayafolineAdisplayspotentanti-neuroinflammatoryeffectbydirectlytargetingtranscriptionfactorSp1inLPS-inducedmicroglialcells.BioorgChem.2022Dec;129:106178.[2].HanJH,etal.MurrayafolineAInducesaG0/G1-PhaseArrestinPlatelet-DerivedGrowthFactor-StimulatedVascularSmoothMuscleCells.KoreanJPhysiolPharmacol.2015Sep;19(5):421-6.[3].ChoiH,etal.MurrayafolineAattenuatestheWnt/beta-cateninpathwaybypromotingthedegradationofintracellularbeta-cateninproteins.BiochemBiophysResCommun.2010Jan1;391(1):915-20.[4].ChidipiB,etal.EnhancementofcontractionandL-typeCa(2+)currentbymurrayafoline-AviaproteinkinaseCinratventricularmyocytes.EurJPharmacol.2016Aug5;784:33-41.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>