Orexin-B-human-13C18-15N3-TFA-Human-orexin-B-sup-13-sup-C-sub-18-sub-sup-15-sup-N-sub-3-sub-TFA-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEOrexinB,human-13C18,15N3TFACat.No.:HY-P1339AS1Synonyms:HumanorexinB-13C18,15N3TFA分⼦式:C₁₀₅₁₃C₁₈H₂₁₂N₄₁₁₅N₃O₃₅S·xC₂HF₃O₂Sequence:Arg-Ser-Gly-Pro-Pro-Gly-{Leu-13C6,15N}-Gln-Gly-Arg-{Leu-13

C6,15N}-Gln-Arg-{Leu-13C6,15N}-Leu-Gln-Ala-Ser-Gly-Asn-Hi

s-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2SequenceShortening:RSGPPG-{Leu-13C6,15N}-QGR-{Leu-13C6,15N}-QR-{Leu-13C6,15N}-LQASGNHAAGILTM-NH2作⽤靶点:Isotope-LabeledCompounds;OrexinReceptor(OXReceptor)作⽤通路:Others;GPCR/GProtein;NeuronalSignaling储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性OrexinB,human-13C18,15N3(HumanorexinB-13C18,15N3)TFA13C和13N标记的OrexinB,human(HY-P1339)。OrexinB,human⾷欲素受体(OrexinReceptor,OXReceptor)的激动剂，对OXR1和OXR2的Ki为420nM和36nM。OrexinB,human参与调节⾷欲、觉醒、⼼⾎管功能和神经内分泌。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].SmartD,etal.Orexins:anewfamilyofneuropeptides.BrJAnaesth.1999Nov;83(5):695-7.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:02