OV329-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemEOV329Cat.No.:HY-179215ACASNo.:2093928-28-8分⼦式:C₇H₇F₂NO₂分⼦量:175.13作⽤靶点:GABAReceptor作⽤通路:MembraneTransporter/IonChannel;NeuronalSignaling储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性OV329⼀种强效的GABA氨转移酶灭活剂。OV329Vigabatrin(HY-15399)的类似物。OV329可提⾼⼤脑中GABA⽔平，并阻断异常的脑内过度兴奋。OV329具有抗惊厥和抗癫痫活性。OV329可⽤于神经系统疾病的研究，如癫痫发作[1]。体内研究OV329(5-40mg/kg,i.p.)showsanticonvulsanteffectinpentylenetetrazole-inducedseizuringrats[1].OV329(30-40mg/kg,i.p.)increasestheafterdischargethresholdinamygdala-kindledrats[1].AnimalModel:Pentylenetetrazole-inducedseizuringWistarUnileverrats[1]Dosage:5,20and40mg/kgAdministration:IntraperitoneallyinjectionResult:Increasedmyoclonicseizurethresholdfromthe15.8to33.1mg/kgat40mg/kg.Increasedclonicseizurethresholdfromthe19.5to40.98mg/kgat40mg/kg.ShowedtheEC50formyoclonicseizuresis25.83mg/kgandforclonicseizuresis20.8mg/kg.Showedtheresponderrateofratsreaches100%atthedoseof40mg/kg.REFERENCES[1].FejaM,etal.OV329,anovelhighlypotentγ-aminobutyricacidaminotransferaseinactivator,inducespronouncedanticonvulsanteffectsinthepentylenetetrazoleseizurethresholdtestandinamygdala-kindledrats.Epilepsia.2021Dec;62(12):3091-3104.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemEMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>