Ruboxistaurin-hydrochloride-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemERuboxistaurinhydrochloride(Standard)Cat.No.:HY-10195BRCASNo.:169939-93-9分⼦式:C₂₈H₂₉ClN₄O₃分⼦量:505.01作⽤靶点:ReferenceStandards;PKC作⽤通路:Others;Epigenetics;TGF-beta/Smad储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Ruboxistaurinhydrochloride(Standard)Ruboxistaurinhydrochloride(HY-10195B)的分析标准品。本产品⽤于研究及分析应⽤。Ruboxistaurin(LY333531)hydrochloride⼀种具有⼝服活性，选择性PKCbeta抑制剂(Ki=2nM)，Ruboxistaurinhydrochloride表现出ATP依赖的竞争性抑制PKCbetaIC50&TargetIC50:4.7nMand5.9nM(PKCβ),Ki:2nM(PKCβ)[1]REFERENCES[1].JirousekMR,etal.(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16,21-dimetheno-1H,13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-dione(LY333531)andrelatedanalogues:isozymeselectiveinhibitorsofproteinkinaseCbeta.JMedChem.1996;39(14):2664-2671.[2].Ruboxistaurin:LY333531.DrugsRD.2007;8(3):193-199.[3].KuntT,etal.Thebeta-specificproteinkinaseCinhibitorruboxistaurin(LY333531)suppressesglucose-inducedadhesionofhumanmonocytestoendothelialcellsinvitro.JDiabetesSciTechnol.2007Nov;1(6):929-35.[4].NonakaA,etal.PKC-betainhibitor(LY333531)attenuatesleukocyteentrapmentinretinalmicrocirculationofdiabeticrats.InvestOphthalmolVisSci.2000Aug;41(9):2702-6.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792a