Rucaparib-monocamsylate-Standard-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemERucaparibmonocamsylate(Standard)Cat.No.:HY-102003RCASNo.:1859053-21-6分⼦式:C₂₉H₃₄FN₃O₅S分⼦量:555.66作⽤靶点:ReferenceStandards;PARP作⽤通路:Others;CellCycle/DNADamage;Epigenetics储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Rucaparibmonocamsylate(Standard)Rucaparibmonocamsylate(HY-102003)的分析标准品。本产品⽤于研究及分析应⽤。Rucaparib(AG014699)monocamsylate⼀种⼝服有效的PARP蛋⽩(PARP-1,PARP-2andPARP-3)抑制剂，对PARP-1的Ki为1.4nM。Rucaparibmonocamsylate六磷酸⼰糖REFERENCES[1].ThomasHD,etal.Preclinicalselectionofanovelpoly(ADP-ribose)polymeraseinhibitorforclinicaltrial.MolCancerTher,2007,6(3),945-956.[2].HunterJE,etal.NF-κBmediatesradio-sensitizationbythePARP-1inhibitor,AG-014699.Oncogene,2012,31(2),251-264.[3].DanielRA,etal.Inhibitionofpoly(ADP-ribose)polymerase-1enhancestemozolomideandtopotecanactivityagainstchildhoodneuroblastoma.ClinCancerRes,2009,15(4),1241-1249.[4].MattShirley,etal.Rucaparib:AReviewinOvarianCancer.TargetOncol.2019Apr;14(2):237-246.[5].JMurray,etal.Tumourcellretentionofrucaparib,sustainedPARPinhibitionandefficacyofweeklyaswellasdailyschedules.BrJCancer.2014Apr15;110(8):1977-84.[6].JiannengLi,etal.Hexose-6-phosphatedehydrogenaseblockadereversesprostatecancerdrugresistanceinxenograftmodelsbyglucocorticoidinactivation.SciTranslMed.2021May26;13(595):eabe8226.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955