SD-208-GMP-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESD-208(GMP)Cat.No.:HY-13227GCASNo.:627536-09-8分⼦式:C₁₇H₁₀ClFN₆分⼦量:352.75作⽤靶点:TGF-βReceptor作⽤通路:TGF-beta/Smad储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性SD-208(GMP)GMP级别的SD-208(HY-13227)。GMP级别的⼩分⼦可⽤做细胞疗法中的辅助试剂。SD-208⼀种选择性的TGF-βRI(ALK5)抑制剂，IC50值为48nM，对其选择性对TGF-βRII的100多倍。体外研究SD-208(GMP)inhibitsthecellgrowthandconstitutiveandTGF-beta-evokedmigrationandinvasion,andenhancesimmunogenicityinmurineSMA-560andhumanLN-308gliomacells[1].SD-208(GMP)blocksTGF-beta-inducedphosphorylationofthereceptor-associatedSmads,Smad2andSmad3,andstimulatesepithelial-to-mesenchymaltransdifferentiation,migration,andinvasivenessintoMatrigelinvitro[2].SD-208(GMP)alsoabolishesthepromotingeffectofTGF-βonneointimalsmoothmuscle-likecell(SMLC)proliferationandmigrationinvitro[3].体内研究SD-208(GMP)(1mg/mL,p.o.)significantlyprolongsthemediansurvivalofSMA-560glioma-bearingmice[1].Insyngeneic129S1mice,SD-208(GMP)(60mg/kg/d,p.o.)inhibitsprimaryR3Ttumorgrowth,andreducesthenumberandthesizeoflungmetastases[2].Inthemurineaorticallograftmodel,SD-208(GMP)effectivelyreducestheformationofintimalhyperplasiaoftransplantarteriosclerosis(TA)[3].户使⽤本产品发表的科研⽂献•CellDeathDis.2024Dec24;15(12):930.•CellRep.2020Apr.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE•JClinTranslHepatol.2023Feb28;11(1):1-14.•CellBiolInt.2020Mar;44(3):861-872.•BrainSci.2021Jan8;11(1):77.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].UhlM,etal.SD-208,anoveltransforminggrowthfactorbetareceptorIkinaseinhibitor,inhibitsgrowthandinvasivenessandenhancesimmunogenicityofmurineandhumangliomacellsinvitroandinvivo.CancerRes.2004Nov1;64(21):7954-61.[2].GeR,etal.Inhibitionofgrowthandmetastasisofmousemammarycarcinomabyselectiveinhibitoroftransforminggrowthfactor-betatypeIreceptorkinaseinvivo.ClinCancerRes.2006Jul15;12(14Pt1):4315-30.[3].SunY,etal.Inhibitionofintimalhyperplasiainmurineaorticallograftsbytheoraladministrationofthetransforminggrowthfactor-betareceptorIkinaseinhibitorSD-208.JHeartLungTransplant.2014Jun;33(6):654-61.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forres