Sodium-propionate-13C-1-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemESodiumpropionate-13C-1Cat.No.:HY-B1773AS1CASNo.:83587-76-2分⼦式:C₂₁₃CH₅NaO₂分⼦量:97.05作⽤靶点:Isotope-LabeledCompounds;EndogenousMetabolite;HSV;

Autophagy;NOSynthase;COX;PPAR;Bacterial;NF-κB;

Apoptosis作⽤通路:Others;MetabolicEnzyme/Protease;Anti-infection;

Autophagy;Immunology/Inflammation;CellCycle/DNA

Damage;VitaminDRelated/NuclearReceptor;NF-κB;

Apoptosis储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性Sodiumpropionate-13C-113C标记的Propionatesodium(HY-B1773A)。Sodiumpropionate⼀种⼝服活性短链脂酸。Sodiumpropionate可由肠道细(bacteria)代谢膳⾷纤维⽽产⽣。Sodiumpropionate增加PPAR-γ，抑制NF-κB活化、降低COX-2表达和NO⽣成。Sodiumpropionate诱导凋亡(Apoptosis)和⾃噬(Autophagy)。Sodiumpropionate减轻HSV-1诱发的眼⾓膜炎。Sodiumpropionate对胶质母细胞瘤具有抗癌作⽤。Sodiumpropionate具有神经保护、抗氧化和抗炎活性。Sodiumpropionate可⽤于脊髓损伤、阿尔茨海默症研究。体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].FilipponeA,etal.SodiumPropionateContributestoTumorCellGrowthInhibitionthroughPPAR-γSignaling.Cancers(Basel).2022Dec29;15(1):217.[2].FilipponeA,etal.Theanti-inflammatoryandantioxidanteffectsofsodiumpropionate.Internationaljournalofmolecularsciences,2020,21(8):3026.[3].FilipponeA,etal.ProtectiveeffectofsodiumpropionateinAβ1-42-inducedneurotoxicityandspinalcordtrauma.Neuropharmacology.2020Apr;166:107977.1/2MasterofBioactiveMolecules—您⾝边的抑制剂⼤师www.MedChemE[4].ParkHS,etal.SodiumpropionateexertsanticancereffectinmicebearingbreastcancercellxenograftbyregulatingJAK2/STAT3/ROS/p38MAPKsignaling.ActaPharmacolSin.2021Aug;42(8):1311-1323.[5].SumbriaD,etal.SupplementingtheDietwithSodiumPropionateSuppressestheSeverityofViralImmuno-inflammatoryLesions.JVirol.2021Jan28;95(4):e02056-20.[6].LangW,etal.SodiumpropionateimprovescognitiveandmemoryfunctioninmousemodelsofAlzheimer'sdisease.NeurosciLett.2022Nov20;791:136887.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearch