2-Deethoxy-2-hydroxyphantomolin-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors • ScreeningLibraries • Proteinswww.MedChemE2-Deethoxy-2-hydroxyphantomolinCat.No.:HY-N17734CASNo.:821799-76-2分子式:C₁₉H₂₂O₆分子量:346.37作用靶点:Bacterial;Fungal作用通路:Anti-infection储存方式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY生物活性2-Deethoxy-2-hydroxyphantomolin，一种germacranolide，是一种抗真菌(antifungal)和抗细菌(antibacterial)剂。2-Deethoxy-2-hydroxyphantomolin可从全草的ElephantopustomentosusLinn和E.mollis的叶子中分离得到。2-Deethoxy-2-hydroxyphantomolin对Candidaalbicans具有中等活性(抑菌圈直径14mm)，对Escherichiacoli(抑菌圈直径12mm)、Pseudomonasaeruginosa(抑菌圈直径12mm)、Bacillussubtilis(抑菌圈直径14mm)以及Trichophytonmentagrophytes(抑菌圈直径13mm)具有轻微活性[1][2]。体外研究2-Deethoxy-2-hydroxyphantomolin(20.0mg/mL;24h)inhibitsStaphylococcusaureuswithaninhibitionzonediameterof31.0mminaninvitrodiskdiffusionassay[1].2-Deethoxy-2-hydroxyphantomolinismoderatelyactiveagainstCandidaalbicans(14mmclearingzone,AI=0.4)andslightlyactiveagainstEscherichiacoli(12mm,AI=0.2),Pseudomonasaeruginosa(12mm,AI=0.2),Bacillussubtilis(14mm,AI=0.4),andTrichophytonmentagrophytes(13mm,AI=0.3),withnoactivityagainstStaphylococcusaureusandAspergillusniger[2].REFERENCESWangB,etal.AnewsesquiterpenelactonefromElephantopustomentosus.JAsianNatProdRes.2012;14(7):700-703.Ragasa,CB,etal.Antimicrobialterpenoidsfromelephantopusmollis.NRCPResearchJournal,2009;10,Issue1,1-6McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>