8R-12R-13R-8-12-Epoxylabd-14-en-13-ol-生命科学试剂-MCE

Hotline:400-820-3792Inhibitors•ScreeningLibraries•Proteinswww.MedChemE(8R,12R,13R)-8,12-Epoxylabd-14-en-13-olCat.No.:HY-N13817CASNo.:56682-25-8分⼦式:C₂₀H₃₄O₂分⼦量:306.48作⽤靶点:NF-κB作⽤通路:NF-κB储存⽅式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY⽣物活性(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol⼀种被发现存在于Abiesgeorgei中的⼆萜类化合物。(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol⼀种核因⼦kappaB(NF-κB)抑制剂，可抑制TNFα触发的NF-κB活性(IC50=8.7μg/mL)。(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol具有抗炎活性，可抑制⼀氧化氮(NO)的产⽣。(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol对肿瘤细胞表现出显著的细胞毒性[1]。体外研究(8R,12R,13R)-8,12-Epoxylabd-14-en-13-ol(Compound54)inhibitsLPS(HY-D1056)-inducedNOproductioninRAW264.7macrophageswithanIC50of21.6μg/mL[1].(8R,12R,13R)-8,12-Epoxylabd-14-en-13-olinhibitsTNFα-triggeredNF-κBactivityinpNF-κB-luc-293cellswithanIC50of8.7μg/mL[1].(8R,12R,13R)-8,12-Epoxylabd-14-en-13-olinhibitsproliferationofLOVOhumantumorcellswithanIC50of23.1μg/mL[1].(8R,12R,13R)-8,12-Epoxylabd-14-en-13-olinhibitsproliferationofQGY-7703humantumorcellswithanIC50of15.7μg/mL[1].REFERENCES[1].YangXW,etal.Isolation,structure,andbioactivitiesofabiesadinesA-Y,25newditerpenesfromAbiesgeorgeiOrr.BioorgMedChem.2010;18(2):744-754.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:02