Beijing supplement Apr 18f martek.ppt

1、北京保健品会议,2008年4月,内 容,Martek介绍 DHA 的定义及主要功效 为什么选择藻油DHA？ DHA在保健品中的应用 Lifes DHA保健品 Lifes DHA在保健品中应用,Martek介绍,Martek Biosciences Corporation,1985年成立，总部在美国马里兰州(NASDAQ-MATK)上市公司 专注于生物科学研究 具有丰富经验的研究团队，集中了大批拥有硕士、博士学历的技术人员 强大的全球合作网络 开发海洋微藻类高价值产品 主要生产 DHA, 品牌为 lifesDHA 配方奶粉 功能性食品 营养品 纯植物来源 DHA 拥有足够资源可持续供货,Fish

2、 eat algae (Uncontrolled most abundant in neural, retinal and CV conducting tissue 含在所有组织里，尤其在神经、视网膜和心血管组织里含量更高 Brain: 97% of n-3 is DHA 大脑中 97%n-3为DHA Retina: 93% of n-3 is DHA 视网膜中93%n-3 为DHA Facilitates synaptic transmission 协调突触传递 Supports myelination 支持髓鞘形成 Influences the speed that information

3、 is acquired and processed 影响获取、处理信息的速度,Docosahexaenoic Acid - DHA 22:6 3,The Distinct Benefits of Omega-3s,认知能力的 发展和作用,视觉的发 展和作用,抗炎功能,心血管功能,维系必需 脂肪酸 的均衡,Retina 视网膜,0,5,10,15,20,25,weight % total fatty acids,n-3,n-6,Brain 大脑,0,5,10,15,20,25,weight % total fatty acids,ALA,EPA,DHA,LA,ARA,Liver 肝,weigh

4、t % total fatty acids,Adipose 结缔组织,0,5,10,15,20,25,weight % total fatty acids,Lauritzen et al (2001) Prog Lipid Res,ALA,EPA,DHA,LA,ARA,ALA,EPA,DHA,LA,ARA,ALA,EPA,DHA,LA,ARA,Only DHA Readily Accumulates in Neural Tissues只有DHA能容易地促进神经组织的发育,DHA is Important Throughout LifeDHA在人体一生中都扮演着重要的作用,Pregnancy孕期

5、,Supports a healthy pregnancy Maternal DHA status母体DHA Increases DHA content of breast milk,Infants 82:125-32,Benefits of Supplemental Martek DHA during Lactation哺乳期 (200 mg/d), and improves in infant psychomotor development,Breast milk n=160,DHA as %TFA,4 mo postpartum,Score,P 0.0001,P = 0.008 afte

6、r Analysis of covariance,Higher scores on sustained attention in children at 5 yrs of age from mothers who supplemented with Martek DHA注意力集中,Leiter Test of sustained attention subtest,Jensen et al. Pediatric Res, 2004;55A,N = 141,P 0.008,DHA Supports Cardiovascular Health in Children and Adults DHA对

7、儿童和成人的心血管健康有益处,Favorable effects on blood lipid profile 对血脂结构的益处 Reduced triglycerides (fasting and following a meal) 降低甘油三酸酯 Increased HDL (good cholesterol) 增加高密度脂蛋白 Improved LDL particle size 改善LDL微粒大小 Modest reductions in blood pressure (higher doses) 适度降低血压(大剂量) Improved arterial compliance Ant

8、i-thrombotic effects Cardiac rhythm 心律 Stabilizes heart rhythm 稳定心律 Lowers heart rate 减少心跳加速,FDA Qualified Health Claim Supportive but not conclusive research shows that consumption of EPA and DHA omega-3 fatty acids may reduce the risk of coronary heart disease. One serving of (name of food) provid

9、es (x) grams of EPA and DHA omega-3 fatty acids.”,DHA in Alzheimers and Dementia DHA同阿兹海默氏症和痴呆症,Calon 2004; Lim 2005 (Journal of Neuroscience) 科伦2004;利姆2005（神经系统科学） Dietary DHA supplementation of transgenic Alzheimers mice:转阿兹海默氏病毒的基因鼠摄入DHA补品： 70% reduction in insoluble plaque 70%降低不溶解性硬块 25% reduct

10、ion in amyloid plaque burden 25%减少淀粉硬块负担 Improvement in learning and memory 提高学习能力和记忆力,Marteks DHA selected for NIH Clinical Trial 美国国家健康局首选马泰克的DHA进行临床试验 DHA (Docosahexaenoic Acid), an Omega 3 Fatty Acid, in Slowing the Progression of Alzheimers Disease DHA（二十二碳六稀酸），一种欧米加 3 脂肪酸，显示出减缓阿兹海默氏疾病恶化的作用 www

11、.,Calon et al. Neuron, 2004, 43:633-45. Lim et al. J Neurosci, 2005, 23:3032-40.,为什么选择藻油DHA？,Fish Consumption Advisories During Pregnancy孕期食用鱼类的注意事项,Women who may become pregnant, pregnant women, nursing mothers, and young children should: 将要怀孕、已怀孕、哺育期和喂养婴幼儿的妇女应该： Not eat fish cont

12、aining high levels of methyl mercury 不应食用甲基汞含量高的鱼类 Limit albacore tuna 限制长鳍金枪鱼的食用量 Intake of fatty fish should not exceed the tolerable intake of environmental contaminants. 高脂鱼的食用量不应超过环境可忍受的捕捞污染度。 Dietary fish should be selected from a wide range of species without undue preference for large predat

13、ory fish such as swordfish and tuna which are more likely to be contaminated with methyl mercury 应食多种类的鱼，而不应偏爱某种食肉鱼如旗鱼和金枪鱼，这些鱼很有可能含甲基汞。,European Expert Consensus Conference (PeriLip),/dms/admehg3.html,/PeriLipRecommendations.html,Fish and Fish Oil Risks are Highly Pub

14、licized,“Worlds supply of Fish in Peril” The Baltimore Sun, 11/03/06 “Mercury in Fish Brings Warning. Pregnant women, kids told of risks” Toronto Star, September 2006 “Mercury a lingering problem despite attempts at regulation” Chicago Tribune, June 2006 “Low Exposure to Organochlorides, Mercury Aff

15、ects Thyroid Status During Pregnancy” Environmental Health Perspectives, June 2006 “Report calls fish grave danger to public health” I, September 2006 “Whole Foods, Safeway, and Wild Oats to Post Seafood Mercury Warnings” , June 21, 2006 “Mercury in tuna: New safety concerns” Consumer Reports, July

16、2006 “Dont Touch the Tuna” Chicago Tribune, June 22, 2006 “Fish Oil May Pose Risk When Pregnant” The Sun Herald, May/June 2006 “Dioxins prompt second UK fish oil withdrawal” N, April 13, 2006 “Cancer fears over cod liver oil capsules” Daily Mail, March 15, 2006 “A New Tuna Warning for Pregnant Women

17、” Los Angeles Times, June 12, 2006 “Catching is Okay, But Eating is Risky” The Washington Post, June 1, 2006 “Avoid Canned Tuna If Pregnant” CBS News, June 6, 2006 “New Warnings on Mercury” Herald Tribune, June 27, 2006,Media Coverage Unlikely To Abate,Lifes DHA在保健品中的应用,软胶囊, 推介DHA对大脑和眼睛的效用 同时推介此产品是全

18、植物来源，不含鱼油 香蕉和草莓口味 目标人群：3岁以上的儿童 DHA含量：125mg/serving,Spectrum 儿童可咀嚼的DHA软胶囊,NuTru O-mega-Zen, 每粒胶囊含有300mg DHA 来自全天然植物,两片装胶囊,Deva - Omega-3 DHA supplement, 对成人的大脑，视力，心脏有益 产品定位纯植物来源,营养棒,Single Layer Extruded,Single Layer Slabbed & Cut,Dual Layer Extruded,Dual,Layered Slabbed & Cut,Baked Bar,营养棒,每天一根45g的营

19、养棒含有正常孕期和哺乳期所必需的营养元素 - DHA，叶酸，蛋白质，维生素A，维生素C，维生素E，维生素B12，维生素B6，铁，镁，锌，钙等,幼儿和孕妇食品,幼儿食品的出现 婴幼儿奶粉公司的新产品延伸 主要瞄准1-3岁或3岁以上的儿童市场 强化DHA的市场认知度并且价位相对比较高端 进入原来传统食品的市场 针对怀孕和哺乳期的妇女 在美国，超过48%针对怀孕的维生素市场（以销售额计）添加了DHA 在两年前只有15%-17%,营养混合物,Nutritional BlendsMeal replacement, weight-loss, body building, sports performanc

20、e, dietary supplement, soups, cereals, pastas, baking mixes, instant drink mixes, as well as other products., Promotes DHA for its brain, eye and heart health benefits Also promotes its vegetarian, non-fish status National Ad promoting that its vegetarian, contaminant free, and has no fishy Taste pa

21、ckage:500ml,Flora - Udos Choice DHA Oil Blend,Food & Beverage Products Containing Marteks lifesDHA,WhiteWave Foods Silk Plus Omega-3 DHA soy milk (U.S.) General Mills Yoplait Kids (U.S.) Latteria Meranos MenteViva (drinkable yogurt) (Italy) Parmalat Australias Vaalia My First Yoghurt (Australia),Ome

22、ga-3 Awareness is Growing,% of General Population Aware of the Terms Omega-3 and DHA,Source: Multisponsor surveys, U.S. population. Data is representative of global awareness trends.,DHA的认知度 不断上升中,Contaminants in Fish Oil are a Real Risk,Quality Control 质量控制问题 An independent study* of 24 commerciall

23、y available fish oil supplements revealed that all contained measurable levels of PCBs 一个中立的研究揭示* ：24种市场上的鱼油补品都含数量不等的可测量的多氯联苯。 2 supplements with Marteks oil were also tested and no PCBs were detected 其中含马泰克藻油的两种补品也被测验 没有发现多氯联苯。 Boots plc withdraws fish oil supplements from the market due to excessive dioxin levels (April, 2006) 英国博姿公司由于其市场上鱼油补品的二恶英含量太高， 撤回其产品（2006年4月）。 Batches of cod liver oil tablets are withdrawn from the market due to excessive dioxin levels (March, 2006) 大批鳕鱼鱼肝油药片由于含过量二恶英从市场撤回（2006年3月）。,* Source: Journal of Food Science, Vol. 68, N